Gene: AT1G42990 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
1 : 16136062-16137459 : negative


Gene family
(16 genes in 13 species)
specific family

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basic region/leucine zipper motif 60
Curated Summary
bZIP60 consists of a bZIP DNA binding domain followed by a putative transmembrane domain. bZIP60 mRNA is upregulated by the addition of ER stress inducers, tunicamycin (inhibitor of N-linked glycosylation), DTT (inhibitor of disulfide bond formation) and azetin-2-carboxylate (proline analog perturbing protein structure). Upon ER stress, bZIP60 mRNA is spliced by IRE1A and IRE1B to produce bZIP60-S, an active transcription factor without the transmembrane domain. bZIP60-U, a product of unspliced form of bZIP60 mRNA, is localized at the ER membrane and bZIP60-S is localized in the nucleus.
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Identifier Name
aliasbasic region/leucine zipper motif 60
aliasBbasic region/leucine zipper motif 60





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006355ISS, IEAGene Ontologyregulation of transcription, DNA-dependent1
GO:0030968IMP, IEP, RCA, UniProtendoplasmic reticulum unfolded protein response1 2 3 4 5 6 7 8 9 10 11 12
GO:0010200IEP, RCA, UniProtresponse to chitin1 2 3 4 5 6 7 8 9 10 11
GO:0000165RCAGene OntologyMAPK cascade1
GO:0002679RCAGene Ontologyrespiratory burst involved in defense response1
GO:0006612RCAGene Ontologyprotein targeting to membrane1
GO:0006984RCAGene OntologyER-nucleus signaling pathway1
GO:0007154RCAGene Ontologycell communication1
GO:0009409RCAGene Ontologyresponse to cold1
GO:0009410RCAGene Ontologyresponse to xenobiotic stimulus1
GO:0009693RCAGene Ontologyethylene biosynthetic process1
GO:0009738RCAGene Ontologyabscisic acid-activated signaling pathway1
GO:0009862RCAGene Ontologysystemic acquired resistance, salicylic acid mediated signaling pathway1
GO:0009867RCAGene Ontologyjasmonic acid mediated signaling pathway1
GO:0009873RCAGene Ontologyethylene mediated signaling pathway1
GO:0010286RCAGene Ontologyheat acclimation1
GO:0010363RCAGene Ontologyregulation of plant-type hypersensitive response1
GO:0031348RCAGene Ontologynegative regulation of defense response1
GO:0034976RCAGene Ontologyresponse to endoplasmic reticulum stress1
GO:0035556RCAGene Ontologyintracellular signal transduction1
GO:0043069RCAGene Ontologynegative regulation of programmed cell death1
GO:0050832RCAGene Ontologydefense response to fungus1
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5 6 7 8 9
GO:2001141IEAPLAZA Homologyregulation of RNA biosynthetic processHOM03M006415

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677ISSGene OntologyDNA binding1
GO:0003700IDA, ISSIEA, UniProtsequence-specific DNA binding transcription factor activity1 2 3 4 5 6 7 8 9 10 11
GO:0043565IEAUniProtsequence-specific DNA binding1 2 3 4 5 6 7 8 9

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5 6 7 8 9 10 11
GO:0005789IDAUniProtendoplasmic reticulum membrane1 2 3 4 5 6 7 8 9 10
GO:0016021IEAUniProtintegral to membrane1 2 3 4 5 6 7 8 9

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR004827Basic-leucine zipper domain

Mapman id Description
27.3.35RNA.regulation of transcription.bZIP transcription factor family
No SignalP domains detected for this gene.