Gene: AT1G29690 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
1 : 10379310-10381861 : negative


Gene family
(107 genes in 14 species)
specific family

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MAC/Perforin domain-containing protein
Curated Summary
Encodes a protein containing a domain with significant homology to the MACPF (membrane attack complex and perforin) domain of complements and perforin proteins that are involved in innate immunity in animals. Transgenic cad1-1 mutant plants show lesions seen in the hypersensitive response, as well as a spontaneous activation of expression of pathogenesis-related genes and leading to a 32-fold increase in salicylic acid (SA). CAD1 is postulated to act as a negative regulator controlling SA-mediated pathway of programmed cell death in plant immunity.
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Identifier Name
aliasconstitutively activated cell death 1





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006955IMPGene Ontologyimmune response1
GO:0008219IMPGene Ontologycell death1
GO:0009626IMPUniProtplant-type hypersensitive response1 2 3 4 5
GO:0010337IMPUniProtregulation of salicylic acid metabolic process1 2 3 4 5
GO:0000165RCAGene OntologyMAPK cascade1
GO:0002679RCAGene Ontologyrespiratory burst involved in defense response1
GO:0006612RCAGene Ontologyprotein targeting to membrane1
GO:0009862RCAGene Ontologysystemic acquired resistance, salicylic acid mediated signaling pathway1
GO:0009867RCAGene Ontologyjasmonic acid mediated signaling pathway1
GO:0010200RCAGene Ontologyresponse to chitin1
GO:0010310RCAGene Ontologyregulation of hydrogen peroxide metabolic process1
GO:0010363RCAGene Ontologyregulation of plant-type hypersensitive response1
GO:0031348RCAGene Ontologynegative regulation of defense response1
GO:0042742RCAGene Ontologydefense response to bacterium1
GO:0043069RCAGene Ontologynegative regulation of programmed cell death1
GO:0050832RCAGene Ontologydefense response to fungus1
GO:0052542RCAGene Ontologydefense response by callose deposition1

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR020864Membrane attack complex component/perforin (MACPF) domain

Mapman id Description
31.5.1cell.cell death.plants
No SignalP domains detected for this gene.