Gene: AT1G28380 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
1 : 9963696-9966060 : positive


Gene family
(107 genes in 14 species)
specific family
(16 genes in 9 species)
specific family

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MAC/Perforin domain-containing protein
Curated Summary
This gene is predicted to encode a protein involved in negatively regulating salicylic acid-related defense responses and cell death programs. nsl1 mutants develop necrotic lesions spontaneously and show other features of a defense response, such as higher levels of SA and disease resistance-related transcripts, in the absence of a biotic stimulus. The NSL1 protein is predicted to have a MACPF domain, found in proteins that form a transmembrane pore in mammalian immune responses. NSL1 transcript levels do not appear to change in response to biotic stresses, but are elevated by cycloheximide in seedlings, and by sodium chloride in roots.
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Identifier Name
aliasnecrotic spotted lesions 1





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006955IMPGene Ontologyimmune response1
GO:0008219IMPGene Ontologycell death1
GO:0009626IMPUniProtplant-type hypersensitive response1 2 3 4 5
GO:0009651TASUniProtresponse to salt stress1 2 3 4 5
GO:0010337IMPUniProtregulation of salicylic acid metabolic process1 2 3 4 5
GO:0052542IMP, RCA, UniProtdefense response by callose deposition1 2 3 4 5 6
GO:0000165RCAGene OntologyMAPK cascade1
GO:0002679RCAGene Ontologyrespiratory burst involved in defense response1
GO:0006612RCAGene Ontologyprotein targeting to membrane1
GO:0006820RCAGene Ontologyanion transport1
GO:0006862RCAGene Ontologynucleotide transport1
GO:0006888RCAGene OntologyER to Golgi vesicle-mediated transport1
GO:0006984RCAGene OntologyER-nucleus signaling pathway1
GO:0009595RCAGene Ontologydetection of biotic stimulus1
GO:0009627RCAGene Ontologysystemic acquired resistance1
GO:0009697RCAGene Ontologysalicylic acid biosynthetic process1
GO:0009862RCAGene Ontologysystemic acquired resistance, salicylic acid mediated signaling pathway1
GO:0009863RCAGene Ontologysalicylic acid mediated signaling pathway1
GO:0009867RCAGene Ontologyjasmonic acid mediated signaling pathway1
GO:0010200RCAGene Ontologyresponse to chitin1
GO:0010310RCAGene Ontologyregulation of hydrogen peroxide metabolic process1
GO:0010363RCAGene Ontologyregulation of plant-type hypersensitive response1
GO:0015696RCAGene Ontologyammonium transport1
GO:0015802RCAGene Ontologybasic amino acid transport1
GO:0031347RCAGene Ontologyregulation of defense response1
GO:0031348RCAGene Ontologynegative regulation of defense response1
GO:0034976RCAGene Ontologyresponse to endoplasmic reticulum stress1
GO:0042742RCAGene Ontologydefense response to bacterium1
GO:0043069RCAGene Ontologynegative regulation of programmed cell death1
GO:0043090RCAGene Ontologyamino acid import1
GO:0043269RCAGene Ontologyregulation of ion transport1
GO:0043900RCAGene Ontologyregulation of multi-organism process1
GO:0045087RCAGene Ontologyinnate immune response1
GO:0050832RCAGene Ontologydefense response to fungus1
GO:0051707RCAGene Ontologyresponse to other organism1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISMGene Ontologynucleus1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR020864Membrane attack complex component/perforin (MACPF) domain

Mapman id Description
35.2not assigned.unknown
No SignalP domains detected for this gene.