Gene: AT1G23260 (Arabidopsis thaliana)

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Gene Identifier
AT1G23260
Transcript Identifier
AT1G23260.1
Gene Type
Coding gene
Location
1 : 8257209-8258573 : negative

Family

Gene family
HOM03M001324
(56 genes in 16 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
MMS ZWEI homologue 1
Curated Summary
MMZ1/UEV1A encodes a protein that may play a role in DNA damage responses and error-free post-replicative DNA repair by participating in lysine-63-based polyubiquitination reactions. UEV1A can form diubiquitin and triubiquitin chains in combination with UBC13A/UBC35 in vitro. It can also functionally complement an mms2 mutation in budding yeast, both by increasing mms2 mutant viability in the presence of the DNA damaging agent MMS, and by reducing the rate of spontaneous DNA mutation. However, a combination of MMZ1/UEV1A and UBC13A do not do a good job of rescuing an mms2 ubc13 double mutant in yeast. MMZ1/UEV1A transcripts are found at low levels in most plant organs, but cannot be detected in the pollen. Transcript levels do not appear to be stress-inducible. The uev1a-1 mutant shows normal sensitivity to MMS in germination assays suggesting that UEV1A is not required for DNA damage tolerance during this developmental stage.
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Identifiers

Identifier Name
aliasMMZ1
aliasUBIQUITIN E2 VARIANT 1A
aliasMMS ZWEI homologue 1
aliasUEV1A
uniprotQ93YP0

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006301IGI, RCA, UniProtpostreplication repair1 2 3 4 5 6
GO:0006623RCAGene Ontologyprotein targeting to vacuole1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004842ISSGene Ontologyubiquitin-protein ligase activity1
GO:0005515IPIGene Ontologyprotein binding1
GO:0016881IEAUniProtacid-amino acid ligase activity1 2 3 4

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISMGene Ontologynucleus1
GO:0031372IPIUniProtUBC13-MMS2 complex1 2 3 4 5

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR016135Ubiquitin-conjugating enzyme/RWD-like
IPR000608Ubiquitin-conjugating enzyme, E2

Mapman id Description
29.5.11.3protein.degradation.ubiquitin.E2
No SignalP domains detected for this gene.