Gene: AT1G08370 (Arabidopsis thaliana)

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Gene Identifier
AT1G08370
Transcript Identifier
AT1G08370.1
Gene Type
Coding gene
Location
1 : 2638355-2640367 : positive

Family

Gene family
HOM03M001763
(45 genes in 16 species)
specific family
Subfamily
ORTHO03M001433
(10 genes in 8 species)
specific family

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Descriptions

Description
decapping 1
Curated Summary
Encodes DCP1 involved in mRNA decapping. DCP1 forms a mRNA decapping complex with DCP2 (At5g13570) and VCS (VARICOSE) (At3g13300). However, unlike DCP2, DCP1 itself does not have mRNA decapping activity in vitro. DCP1, DCP2 and VCS colocalize in cytoplasmic loci, which are putative Arabidopsis mRNA processing bodies. Null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. The protein was shown by immunoprecipitation not to interact with DCP2.
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Identifiers

Identifier Name
aliasATDCP1
aliasDCP1
aliasdecapping 1
uniprotQ9SJF3

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0031087IDAUniProtdeadenylation-independent decapping of nuclear-transcribed mRNA1 2 3 4 5
GO:0000278RCAGene Ontologymitotic cell cycle1
GO:0006396RCAGene OntologyRNA processing1
GO:0006397IEAUniProtmRNA processing1 2 3 4
GO:0031086IEAPLAZA Homologynuclear-transcribed mRNA catabolic process, deadenylation-independent decayHOM03M001763

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515IPIGene Ontologyprotein binding1
GO:0042803IPIGene Ontologyprotein homodimerization activity1
GO:0050072IDAGene Ontologym7G(5')pppN diphosphatase activity1
GO:0016787IEAUniProthydrolase activity1 2 3 4

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISMGene Ontologynucleus1
GO:0000932IDA, NAS, UniProtcytoplasmic mRNA processing body1 2 3 4 5 6
GO:0005737IDAGene Ontologycytoplasm1

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR010334Dcp1-like decapping
IPR011993Pleckstrin homology-like domain

Mapman id Description
27.1RNA.processing
No SignalP domains detected for this gene.