Gene: AT1G08130 (Arabidopsis thaliana)

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Gene Identifier
AT1G08130
Transcript Identifier
AT1G08130.1
Gene Type
Coding gene
Location
1 : 2542913-2547815 : negative

Family

Gene family
HOM03M000926
(76 genes in 16 species)
specific family

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Descriptions

Description
DNA ligase 1
Curated Summary
Encodes the Arabidopsis DNA ligase 1 that provides the major DNA ligase activity in cells and plays a key role in both DNA replication and excision repair pathways. Indispensable for cell viability. AtLIG1 expresses one major and two minor mRNA transcripts differing only in the length of the 5' untranslated leader sequences preceding a common ORF. Translation from the first in-frame start codon produces an AtLIG1 isoform that is targeted exclusively to the mitochondria. Translation initiation from the second in-frame start codon produces an AtLIG1 isoform targeted only to the nucleus.
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Identifiers

Identifier Name
aliasDNA ligase 1
aliasLIG1
aliasATLIG1
uniprotQ42572

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006266IBAGene OntologyDNA ligation1
GO:0000012IMPUniProtsingle strand break repair1 2 3 4 5 6 7 8 9
GO:0006260IMP, IEA, UniProtDNA replication1 2 3 4 5 6 7 8 9
GO:0006302IMPUniProtdouble-strand break repair1 2 3 4 5 6 7 8 9
GO:0006261RCAGene OntologyDNA-dependent DNA replication1
GO:0009909RCAGene Ontologyregulation of flower development1
GO:0016458RCAGene Ontologygene silencing1
GO:0016570RCAGene Ontologyhistone modification1
GO:0034968RCAGene Ontologyhistone lysine methylation1
GO:0048449RCAGene Ontologyfloral organ formation1
GO:0007049IEAUniProtcell cycle1 2 3 4 5 6 7 8
GO:0051301IEAUniProtcell division1 2 3 4 5 6 7 8
GO:0051103IEAUniProtDNA ligation involved in DNA repair1 2 3 4 5 6 7 8
GO:0006310IEAUniProtDNA recombination1 2 3 4 5 6 7 8
GO:0006281IEAInterProDNA repair

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003910IBA, ISSIEA, UniProtDNA ligase (ATP) activity1 2 3 4 5 6 7 8 9 10
GO:0005524IEA, ISSUniProtATP binding1 2 3 4 5 6 7 8 9
GO:0003677IEAUniProtDNA binding1 2 3 4 5 6 7 8
GO:0046872IEAUniProtmetal ion binding1 2 3 4 5 6 7 8
GO:0003909IEAInterProDNA ligase activity
GO:0097159IEAPLAZA Homologyorganic cyclic compound bindingHOM03M000926
GO:0016787IEAPLAZA Homologyhydrolase activityHOM03M000926
GO:1901363IEAPLAZA Homologyheterocyclic compound bindingHOM03M000926
GO:0005488IEAPLAZA HomologybindingHOM03M000926

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5 6 7 8 9 10
GO:0005739IDAUniProtmitochondrion1 2 3 4 5 6 7 8 9

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR012308DNA ligase, ATP-dependent, N-terminal
IPR012310DNA ligase, ATP-dependent, central
IPR000977DNA ligase, ATP-dependent
IPR016059DNA ligase, ATP-dependent, conserved site
IPR012340Nucleic acid-binding, OB-fold
IPR012309DNA ligase, ATP-dependent, C-terminal

Mapman id Description
28.1DNA.synthesis/chromatin structure
No SignalP domains detected for this gene.