Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This domain is the proposed leucine zipper at the N terminus of VPS13A and related proteins. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport [1].

1. Brain-specific transcript variants of 5' and 3' ends of mouse VPS13A and VPS13C. Biochem. Biophys. Res. Commun. 353, 902-7

Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrate
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