The RWD domain is a conserved region of about 110 amino acid residues, whichhas been identified in the mouse GCN2 eIF2alpha kinase and histidyl-tRNAsynthetase and in presumed orthologues in other eukaryotic species from yeast tovertebrates. Additionally, it is also found in WD repeat containing proteins,yeast DEAD (DEXD)-like helicases, many RING-finger containing proteins, theUPF0029 uncharacterised protein family and a range of hypothetical proteins. The RWD domain has been named after the better characterised RING finger and WD repeat containing proteins and DEAD-like helicases. It has been proposed that the RWD domain might have a function in protein interaction [1].

The RWD domain is predicted to have an alpha/beta secondary structure and isthought to be related to ubiquitin-conjugating enzymes (UBCc) domain, althoughthe catalytic cysteine critical for ubiquitin-conjugating activity is notconserved in most members of the novel subfamily [2].

1. Systematic identification of novel protein domain families associated with nuclear functions. Genome Res. 12, 47-56

The RWD domain is a conserved region of about 110 amino acid residues, whichhas been identified i
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