This entry represents a susbset of the wider APC (Amino acid-Polyamine-organoCation) superfamily of transporters [1]. Characterised proteins in this entry include:

• Xanthine permease PbuX, involved in cellualar xanthine transport [2]
• Uric acid permeases which promotes uptake of uric acid into the cell in limiting-nitrogen conditions [3]
• Uracil permease [4]
• Sodium-dependent vitamin C transporter, a sodium/ascorbate cotransporter mediating electrogenic uptake of Vitamin C [5]

These proteins generally contain 12 transmembrane regions. Many members of this family are uncharacterised and may transport other substrates eg. RutG is likely to transport pyrimidines into the cell [6].

1. The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations. Microbiology (Reading, Engl.) 146 ( Pt 8), 1797-814
2. Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism. J. Bacteriol. 179, 2540-50
3. Functional analysis of 14 genes that constitute the purine catabolic pathway in Bacillus subtilis and evidence for a novel regulon controlled by the PucR transcription activator. J. Bacteriol. 183, 3293-302
4. The pyrimidine biosynthesis operon of the thermophile Bacillus caldolyticus includes genes for uracil phosphoribosyltransferase and uracil permease. J. Bacteriol. 176, 3698-707
5. Vitamin C transport systems of mammalian cells. Mol. Membr. Biol. 18, 87-95
6. A previously undescribed pathway for pyrimidine catabolism. Proc. Natl. Acad. Sci. U.S.A. 103, 5114-9

This entry represents a susbset of the wider APC (Amino acid-Polyamine-organoCation) superfamily
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