Eukaryotic initiation factor 5A (eIF-5A), now considered to be an elongation factor (see IPR001884), contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in thepost-translational formation of hypusine is catalysed by the enzymedeoxyhypusine synthase (DS) 2.5.1.46. The enzyme catalyses the following reaction:Spermidine + [eIF-5A]-lysine = 1,3-diaminopropane + [eIF-5A]-deoxyhypusineThe modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation [1]. The structure is known for this enzyme [2] in complex with its NAD⁺ cofactor.

1. Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site. Structure 6, 23-32

Eukaryotic initiation factor 5A (eIF-5A), now considered to be an elongation factor (see Show more...

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