This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1) [1], human tyrosyl-tRNA synthetase [2],and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases [3]. In human tyrosyl-tRNA synthetase this domain may directtRNA to the active site of the enzyme [3]. This domain may perform acommon function in tRNA aminoacylation [3].

1. The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases. EMBO J. 15, 5437-48
2. Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine. J. Biol. Chem. 272, 14420-5

This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA syn
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