Proteins in this entry play a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). They directly bind tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether the protein actph as a sulphurtransferase that transfers sulphur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position [1].

1. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Proc. Natl. Acad. Sci. U.S.A. 105, 18255-60

Proteins in this entry play a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of
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