Gene: AT5G66750 (Arabidopsis thaliana)

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Gene Identifier
AT5G66750
Transcript Identifier
AT5G66750.1
Gene Type
Coding gene
Location
5 : 26649050-26652869 : positive

Family

Gene family
HOM03D000113
(850 genes in 31 species)
specific family

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Descriptions

Description
chromatin remodeling 1
Curated Summary
Protein is similar to SWI2/SNF2 chromatin remodeling proteins. DDM1 is appears to act as a chromatin-remodeling ATPase involved in cytosine methylation in CG and non-CG contexts. Involved in gene silencing and maintenance of DNA methylation and histone methylation. Hypomethylation of many genomic regions occurs in ddm1 mutants, and can cause several phenotypic abnormalities, but some loci, such as BONSAI (At1g73177) can be hypermethylated in ddm1 mutants after several generations, leading to different phenotypes. DDM1 might be involved in establishing a heterochromain boundary. A line expressing an RNAi targeted against DDM1 shows some resistance to agrobacterium-mediated root transformation.
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Identifiers

Identifier Name
aliasSOMNIFEROUS 1
aliasCHA1
aliasCHR01
aliasCHROMATIN REMODELING 1
aliasDDM1
aliasATDDM1
aliasCHR1
aliaschromatin remodeling 1
aliasSOM4
aliasSOM1
aliasDECREASED DNA METHYLATION 1
uniprotQ9XFH4

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006349IMPUniProtregulation of gene expression by genetic imprinting1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44
GO:0044030IMPUniProtregulation of DNA methylation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44
GO:0051574IMPUniProtpositive regulation of histone H3-K9 methylation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44
GO:0090241IMPUniProtnegative regulation of histone H4 acetylation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44
GO:0006344IMPUniProtmaintenance of chromatin silencing1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44
GO:0009294IMPUniProtDNA mediated transformation1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44
GO:0032197IMPUniProttransposition, RNA-mediated1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44
GO:0006342RCAGene Ontologychromatin silencing1
GO:0006346IMP, RCA, UniProtmethylation-dependent chromatin silencing1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45
GO:0008283RCAGene Ontologycell proliferation1
GO:0016246RCAGene OntologyRNA interference1
GO:0016572RCAGene Ontologyhistone phosphorylation1
GO:0031048RCAGene Ontologychromatin silencing by small RNA1
GO:0051567RCAGene Ontologyhistone H3-K9 methylation1
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004386ISS, IEAGene Ontologyhelicase activity1
GO:0004003IMPUniProtATP-dependent DNA helicase activity1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44
GO:0016887IDAGene OntologyATPase activity1
GO:0005515IPIGene Ontologyprotein binding1
GO:0003676IEAInterPronucleic acid binding
GO:0003677IEAUniProtDNA binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43
GO:0005524IEAUniProtATP binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43
GO:0032555IEAPLAZA Homologypurine ribonucleotide bindingHOM03D000113
GO:0016817IEAPLAZA Homologyhydrolase activity, acting on acid anhydridesHOM03D000113
GO:0032553IEAPLAZA Homologyribonucleotide bindingHOM03D000113
GO:0043168IEAPLAZA Homologyanion bindingHOM03D000113
GO:0043167IEAPLAZA Homologyion bindingHOM03D000113
GO:0035639IEAPLAZA Homologypurine ribonucleoside triphosphate bindingHOM03D000113
GO:0097367IEAPLAZA Homologycarbohydrate derivative bindingHOM03D000113
GO:0016818IEAPLAZA Homologyhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesHOM03D000113
GO:0032559IEAPLAZA Homologyadenyl ribonucleotide bindingHOM03D000113
GO:1901265IEAPLAZA Homologynucleoside phosphate bindingHOM03D000113
GO:0016462IEAPLAZA Homologypyrophosphatase activityHOM03D000113
GO:0000166IEAPLAZA Homologynucleotide bindingHOM03D000113
GO:0030554IEAPLAZA Homologyadenyl nucleotide bindingHOM03D000113
GO:0001882IEAPLAZA Homologynucleoside bindingHOM03D000113
GO:0097159IEAPLAZA Homologyorganic cyclic compound bindingHOM03D000113
GO:0017076IEAPLAZA Homologypurine nucleotide bindingHOM03D000113
GO:0017111IEAPLAZA Homologynucleoside-triphosphatase activityHOM03D000113
GO:0036094IEAPLAZA Homologysmall molecule bindingHOM03D000113
GO:0032549IEAPLAZA Homologyribonucleoside bindingHOM03D000113
GO:0016787IEAPLAZA Homologyhydrolase activityHOM03D000113
GO:1901363IEAPLAZA Homologyheterocyclic compound bindingHOM03D000113
GO:0001883IEAPLAZA Homologypurine nucleoside bindingHOM03D000113
GO:0032550IEAPLAZA Homologypurine ribonucleoside bindingHOM03D000113

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IEA, ISMUniProtnucleus1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44
GO:0000786IDAUniProtnucleosome1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001650Helicase, C-terminal
IPR000330SNF2-related
IPR014001Helicase, superfamily 1/2, ATP-binding domain
IPR027417P-loop containing nucleoside triphosphate hydrolase

Mapman id Description
27.3.44RNA.regulation of transcription.Chromatin Remodeling Factors
No SignalP domains detected for this gene.
DatabaseType
PlnTFDBSNF2