Gene: AT5G64813 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
5 : 25910836-25912625 : positive


Gene family
(48 genes in 28 species)
specific family
Duplication type
Block duplicate

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Ras-related small GTP-binding family protein
Curated Summary
The LIP1 gene encodes a small GTPase that influences the light input pathway of the plant circadian network. An MBP:LIP1 fusion protein has GTP hydrolyzing abilities in vitro. In plants, LIP1 seems to play a negative role in regulating circadian period that can be suppressed by light. LIP1 also seems to negatively affect light-pulse-dependent resetting of the clock, especially during the first portion of the subjective evening. LIP1 expression levels are not significantly affected by the circadian clock in seedlings grown under LL conditions. The levels of the YFP:LIP1 protein expressed under the control of the 35S promoter, shows a low amplitude variation, with protein levels peaking near the beginning of subjective night under LL conditions. In hypocotyl epidermal cells of dark and light-grown seedlings, a YFP:LIP1 fusion protein can be seen in the cytoplasm and the nucleus, and does not cluster in nuclear speckles. LIP1 may also be involved in photomorphogenesis.
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Identifier Name
aliasLight Insensitive Period1





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0009640IMPUniProtphotomorphogenesis1 2 3 4
GO:0032922IMPUniProtcircadian regulation of gene expression1 2 3 4
GO:0007264IEAUniProtsmall GTPase mediated signal transduction1 2 3
GO:0015031IEAInterProprotein transport

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003924IDAUniProtGTPase activity1 2 3 4
GO:0005525IEAUniProtGTP binding1 2 3

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5
GO:0005737IDAUniProtcytoplasm1 2 3 4
GO:0005622IEAPLAZA HomologyintracellularHOM03D003874

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR001806Small GTPase superfamily
IPR003579Small GTPase superfamily, Rab type
IPR025662Sigma-54 interaction domain, ATP-binding site 1

Mapman id Description
No SignalP domains detected for this gene.