Gene: AT5G41370 (Arabidopsis thaliana)

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Gene Identifier
AT5G41370
Transcript Identifier
AT5G41370.1
Gene Type
Coding gene
Location
5 : 16551337-16555792 : positive

Family

Gene family
HOM03D004472
(44 genes in 28 species)
specific family
Duplication type
Tandem duplicate

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Descriptions

Description
homolog of xeroderma pigmentosum complementation group B 1
Curated Summary
Encodes XPB1, a DNA repair protein and transcription factor. Arabidopsis thaliana has duplicated XPB gene (AtXPB1 and AtXPB2, with high similarity to each other). XPB proteins are involved in both DNA repair and transcription, they are component of the transcription factor IIH (TFIIH) and are responsible for DNA helicase activity during nucleotide (nt) excision repair (NER). Complementation assays in yeast rad25 mutant strains suggest the involvement of AtXPB2 in DNA repair. Although both genes are expressed in a constitutive manner during the plant life cycle, Northern blot analyses suggest that light modulates the expression level of both XPB copies.
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Identifiers

Identifier Name
aliasATXPB1
aliashomolog of xeroderma pigmentosum complementation group B 1
aliasARABIDOPSIS HOMOLOG OF XERODERMA PIGMENTOSUM COMPLEMENTATION GROUP B 1
aliasXPB1
uniprotQ38861

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0009636IMPGene Ontologyresponse to toxic substance1 AGRICOLA_IND:IND23277341
GO:0009411IEPUniProtresponse to UV1 2 3 4 5 6
GO:0006289IEAUniProtnucleotide-excision repair1 2 3 4 5
GO:0006355IEAUniProtregulation of transcription, DNA-dependent1 2 3 4 5
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0008026ISSGene OntologyATP-dependent helicase activity1
GO:0004003IEAUniProtATP-dependent DNA helicase activity1 2 3 4 5
GO:0016787IEAInterProhydrolase activity
GO:0004386IEAInterProhelicase activity
GO:0003676IEAInterPronucleic acid binding
GO:0003677IEAUniProtDNA binding1 2 3 4 5
GO:0005524IEAUniProtATP binding1 2 3 4 5

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5 6 7
GO:0005737IDAUniProtcytoplasm1 2 3 4 5 6

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001650Helicase, C-terminal
IPR001161Helicase Ercc3
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR006935Helicase/UvrB domain
IPR014001Helicase, superfamily 1/2, ATP-binding domain

Mapman id Description
28.2DNA.repair
No SignalP domains detected for this gene.