Gene: AT5G19400 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT5G19400
Transcript Identifier
AT5G19400.1
Gene Type
Coding gene
Location
5 : 6540603-6544262 : positive

Family

Gene family
HOM03D001885
(90 genes in 29 species)
specific family
Subfamily
ORTHO03D001683
(47 genes in 28 species)
specific family

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Descriptions

Description
Telomerase activating protein Est1
Curated Summary
Encodes SMG7, a protein that possesses an evolutionarily conserved EST1 domain and exhibits strong homology to human SMG6 (EST1A) and SMG7 (EST1C) proteins. SMG7 plays an evolutionarily conserved role in nonsense-mediated RNA decay (NMD). Required for exit from meiosis. Hypomorphic smg7 alleles render mutant plants sterile by causing an unusual cell-cycle arrest in anaphase II that is characterized by delayed chromosome decondensation and aberrant rearrangement of the meiotic spindle. Disruption of SMG7 causes embryonic lethality.
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Identifiers

Identifier Name
aliasSMG7
uniprotA9QM73

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0000184IMPUniProtnuclear-transcribed mRNA catabolic process, nonsense-mediated decay1 2 3 4 5 6
GO:0007126IMPGene Ontologymeiosis1
GO:0090306IMPUniProtspindle assembly involved in meiosis1 2 3 4 5 6
GO:0006952IEAUniProtdefense response1 2 3 4 5
GO:0007275IEAUniProtmulticellular organismal development1 2 3 4 5
GO:0040008IEAUniProtregulation of growth1 2 3 4 5

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515IEAPLAZA Homologyprotein bindingHOM03D001885

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5 6 7
GO:0000932IDAUniProtcytoplasmic mRNA processing body1 2 3 4 5 6

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR019458Telomerase activating protein Est1
IPR018834DNA/RNA-binding domain, Est1-type

Mapman id Description
35.2not assigned.unknown
No SignalP domains detected for this gene.