Gene: AT4G34350 (Arabidopsis thaliana)

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Gene Identifier
AT4G34350
Transcript Identifier
AT4G34350.1
Gene Type
Coding gene
Location
4 : 16428681-16431038 : negative

Family

Gene family
HOM03D003312
(55 genes in 31 species)
specific family
Subfamily
ORTHO03D002245
(43 genes in 31 species)
specific family

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Descriptions

Description
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Curated Summary
Arabidopsis ISPH is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. It was shown to complement the lethal phenotype of E. coli ispH mutant and is therefore most likely encodes a protein with 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity involved in the last step of mevalonate-independent isopentenyl biosynthesis. Mutant has Albino seedling.
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Identifiers

Identifier Name
alias4-hydroxy-3-methylbut-2-enyl diphosphate reductase
aliasHDR
aliasISPH
aliasCHLOROPLAST BIOGENESIS 6
aliasCLB6
uniprotQ94B35

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0019288IGI, IEP, ISSIEA, UniProtisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway1 2 3 4 5 6 7 8 9
GO:0046677ISSGene Ontologyresponse to antibiotic1
GO:0055114IEAInterProoxidation-reduction process
GO:0050992IEAUniProtdimethylallyl diphosphate biosynthetic process1 2 3 4 5 6
GO:0016114ISOPLAZA Integrative Orthologyterpenoid biosynthetic processOS03G52170

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0046429IMPUniProt4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity1 2 3 4 5 6 7
GO:0051745IGIUniProt4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity1 2 3 4 5 6 7
GO:0051538IEAUniProt3 iron, 4 sulfur cluster binding1 2 3 4 5 6
GO:0046872IEAUniProtmetal ion binding1 2 3 4 5 6

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0009570IDAUniProtchloroplast stroma1 2 3 4 5 6 7
GO:0009507IDAGene Ontologychloroplast1

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003451LytB protein

Mapman id Description
16.1.1.7secondary metabolism.isoprenoids.non-mevalonate pathway.HDR
No SignalP domains detected for this gene.