Gene: AT4G22970 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT4G22970
Transcript Identifier
AT4G22970.1
Gene Type
Coding gene
Location
4 : 12033703-12043572 : negative

Family

Gene family
HOM03D003069
(59 genes in 30 species)
specific family
Subfamily
ORTHO03D003527
(37 genes in 27 species)
specific family

Loading...please wait

Descriptions

Description
homolog of separase
Curated Summary
Encodes a separase (ESP), homologous to human and mouse separase protein. Separase is a capase family protease required for the release of sister chromatid cohesion during meiosis and mitosis. Arabidopsis separase contains a predicted 2Fe2S-ferredoxin domain that is not present in the proteins of other organisms. Also contains a putative EF-hand calcium binding domain. Mutant seeds exhibited embryo arrest at the globular stage. The endosperm also exhibited a weak titan-like phenotype. Transgenic plants expressing AESP RNA interference (RNAi) from the meiosis-specific DMC1 promoter exhibited alterations in chromosome segregation during meiosis I and II that resulted in polyads containing from one to eight microspores. Plays an essential role in embryo development. Required for the removal of cohesin from meiotic chromosomes and establishment of meiotic nuclear domains. This gene was also identified through the rsw4 mutant. Lines carrying recessive, temperature-sensitive mutations exhibit reduced anisotropic growth at 30 degrees Celsius. Microtubules and cellulose microfibrils are not depleted or disoriented in the mutants at the restrictive temperature.
Show more...

Identifiers

Identifier Name
aliasRSW4
aliasEXTRA SPINDLE POLES
aliasESP
aliasRADIALLY SWOLLEN 4
aliasAESP
aliashomolog of separase
uniprotQ5IBC5

Toolbox

Explore

View

 

Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0009826IMPUniProtunidimensional cell growth1 2 3 4 5 6
GO:0009793IMP, RCA, UniProtembryo development ending in seed dormancy1 2 3 4 5 6 7
GO:0009960IMPUniProtendosperm development1 2 3 4 5 6
GO:0045876IMPUniProtpositive regulation of sister chromatid cohesion1 2 3 4 5 6
GO:0051307IMPUniProtmeiotic chromosome separation1 2 3 4 5 6
GO:0051304IMPGene Ontologychromosome separation1
GO:0000003RCAGene Ontologyreproduction1
GO:0000278RCAGene Ontologymitotic cell cycle1
GO:0000280RCAGene Ontologynuclear division1
GO:0000911RCAGene Ontologycytokinesis by cell plate formation1
GO:0006259RCAGene OntologyDNA metabolic process1
GO:0006275RCAGene Ontologyregulation of DNA replication1
GO:0006302RCAGene Ontologydouble-strand break repair1
GO:0006310RCAGene OntologyDNA recombination1
GO:0006312RCAGene Ontologymitotic recombination1
GO:0006325RCAGene Ontologychromatin organization1
GO:0006342RCAGene Ontologychromatin silencing1
GO:0006396RCAGene OntologyRNA processing1
GO:0007062RCAGene Ontologysister chromatid cohesion1
GO:0007067IEA, RCAUniProtmitosis1 2 3 4 5 6
GO:0007126RCAGene Ontologymeiosis1
GO:0007129RCAGene Ontologysynapsis1
GO:0007131RCAGene Ontologyreciprocal meiotic recombination1
GO:0008284RCAGene Ontologypositive regulation of cell proliferation1
GO:0009640RCAGene Ontologyphotomorphogenesis1
GO:0009845RCAGene Ontologyseed germination1
GO:0009880RCAGene Ontologyembryonic pattern specification1
GO:0009887RCAGene Ontologyorgan morphogenesis1
GO:0009888RCAGene Ontologytissue development1
GO:0009909RCAGene Ontologyregulation of flower development1
GO:0009933RCAGene Ontologymeristem structural organization1
GO:0010072RCAGene Ontologyprimary shoot apical meristem specification1
GO:0010090RCAGene Ontologytrichome morphogenesis1
GO:0010162RCAGene Ontologyseed dormancy process1
GO:0010182RCAGene Ontologysugar mediated signaling pathway1
GO:0010228RCAGene Ontologyvegetative to reproductive phase transition of meristem1
GO:0010332RCAGene Ontologyresponse to gamma radiation1
GO:0010389RCAGene Ontologyregulation of G2/M transition of mitotic cell cycle1
GO:0010431RCAGene Ontologyseed maturation1
GO:0010564RCAGene Ontologyregulation of cell cycle process1
GO:0010638RCAGene Ontologypositive regulation of organelle organization1
GO:0016567RCAGene Ontologyprotein ubiquitination1
GO:0016572RCAGene Ontologyhistone phosphorylation1
GO:0019915RCAGene Ontologylipid storage1
GO:0031048RCAGene Ontologychromatin silencing by small RNA1
GO:0032204RCAGene Ontologyregulation of telomere maintenance1
GO:0032504RCAGene Ontologymulticellular organism reproduction1
GO:0033044RCAGene Ontologyregulation of chromosome organization1
GO:0042023RCAGene OntologyDNA endoreduplication1
GO:0042138RCAGene Ontologymeiotic DNA double-strand break formation1
GO:0043247RCAGene Ontologytelomere maintenance in response to DNA damage1
GO:0045132RCAGene Ontologymeiotic chromosome segregation1
GO:0045595RCAGene Ontologyregulation of cell differentiation1
GO:0045893RCAGene Ontologypositive regulation of transcription, DNA-dependent1
GO:0048366RCAGene Ontologyleaf development1
GO:0048825RCAGene Ontologycotyledon development1
GO:0050826RCAGene Ontologyresponse to freezing1
GO:0051225RCAGene Ontologyspindle assembly1
GO:0051276RCAGene Ontologychromosome organization1
GO:0051301IEA, RCAUniProtcell division1 2 3 4 5 6
GO:0051567RCAGene Ontologyhistone H3-K9 methylation1
GO:0006508IEAUniProtproteolysis1 2 3 4 5

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0008233ISS, IEA, UniProtpeptidase activity1 2 3 4 5 6
GO:0005515IEAInterProprotein binding

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IEA, ISSUniProtnucleus1 2 3 4 5 6

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR011990Tetratricopeptide-like helical
IPR005314Peptidase C50, separase

Mapman id Description
35.2not assigned.unknown
No SignalP domains detected for this gene.