Gene: AT4G16340 (Arabidopsis thaliana)

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Gene Identifier
AT4G16340
Transcript Identifier
AT4G16340.1
Gene Type
Coding gene
Location
4 : 9228773-9241060 : negative

Family

Gene family
HOM03D003039
(59 genes in 29 species)
specific family
Subfamily
ORTHO03D010906
(24 genes in 23 species)
specific family

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Descriptions

Description
guanyl-nucleotide exchange factors;GTPase binding;GTP binding
Curated Summary
Encodes SPIKE1 (SPK1), the lone DOCK family guanine nucleotide exchange factor (GEF) in Arabidopsis. SPK1 is a peripheral membrane protein that accumulates at, and promotes the formation of, a specialized domain of the endoplasmic reticulum (ER) termed the ER exit site (ERES). SPK1 promotes polarized growth and cell-cell adhesion in the leaf epidermis. Mutant has seedling lethal; cotyledon, leaf-shape, trichome defects.
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Identifiers

Identifier Name
aliasSPIKE1
aliasSPK1

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0016192IMPGene Ontologyvesicle-mediated transport1
GO:0000226RCAGene Ontologymicrotubule cytoskeleton organization1
GO:0000911RCAGene Ontologycytokinesis by cell plate formation1
GO:0006084RCAGene Ontologyacetyl-CoA metabolic process1
GO:0007020RCAGene Ontologymicrotubule nucleation1
GO:0009855RCAGene Ontologydetermination of bilateral symmetry1
GO:0010014RCAGene Ontologymeristem initiation1
GO:0010073RCAGene Ontologymeristem maintenance1
GO:0010075RCAGene Ontologyregulation of meristem growth1
GO:0010090RCAGene Ontologytrichome morphogenesis1
GO:0016126RCAGene Ontologysterol biosynthetic process1
GO:0016132RCAGene Ontologybrassinosteroid biosynthetic process1
GO:0045010RCAGene Ontologyactin nucleation1
GO:0007264IEAInterProsmall GTPase mediated signal transduction

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005085IEAInterProguanyl-nucleotide exchange factor activity

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISMGene Ontologynucleus1 2
GO:0005886IDAGene Ontologyplasma membrane1
GO:0005829IDA, RCAGene Ontologycytosol1 2
GO:0019898IDAGene Ontologyextrinsic to membrane1
GO:0070971IDAGene Ontologyendoplasmic reticulum exit site1

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR027007DHR-1 domain
IPR027357DHR-2 domain
IPR010703Dedicator of cytokinesis C-terminal
IPR026791Dedicator of cytokinesis

Mapman id Description
31.1cell.organisation
No SignalP domains detected for this gene.