Gene: AT4G14880 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT4G14880
Transcript Identifier
AT4G14880.1
Gene Type
Coding gene
Location
4 : 8518209-8520050 : negative

Family

Gene family
HOM03D000333
(354 genes in 31 species)
specific family
Subfamily
ORTHO03D004030
(36 genes in 21 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
O-acetylserine (thiol) lyase (OAS-TL) isoform A1
Curated Summary
Encodes a cytosolic isoform of cytosolic O-acetylserine(thiol)lyase, a key enzyme in cysteine biosynthesis and for the fixation of inorganic sulfide. It catalyzes the formation of cysteine from O-acetylserine and inorganic sulfide. Gene expression is predominant in the root cortex and the xylem parenchyma. Gene expression is induced in leave, stems and roots by high salt and heavy metal stresses, mediated by ABA. Lines carrying semi-dominant mutations exhibit early senescence.
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Identifiers

Identifier Name
aliasO-acetylserine (thiol) lyase (OAS-TL) isoform A1
aliasOLD3
aliasCYTACS1
aliasOASA1
aliasONSET OF LEAF DEATH 3
aliasATCYS-3A
uniprotP47998

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006535TAS, IEA, UniProtcysteine biosynthetic process from serine1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
GO:0046686IDA, IEP, IMPRCA, UniProtresponse to cadmium ion1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
GO:0007568IMPUniProtaging1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
GO:0019344IMP, RCAGene Ontologycysteine biosynthetic process1 2
GO:0006094RCAGene Ontologygluconeogenesis1
GO:0006096RCAGene Ontologyglycolysis1
GO:0006816RCAGene Ontologycalcium ion transport1
GO:0006833RCAGene Ontologywater transport1
GO:0006972RCAGene Ontologyhyperosmotic response1
GO:0007030RCAGene OntologyGolgi organization1
GO:0009266RCAGene Ontologyresponse to temperature stimulus1
GO:0009611RCAGene Ontologyresponse to wounding1
GO:0009651RCAGene Ontologyresponse to salt stress1
GO:0009684RCAGene Ontologyindoleacetic acid biosynthetic process1
GO:0009805RCAGene Ontologycoumarin biosynthetic process1
GO:0009853RCAGene Ontologyphotorespiration1
GO:0019761RCAGene Ontologyglucosinolate biosynthetic process1
GO:0010043ISOPLAZA Tree-based Orthologyresponse to zinc ionAT3G22460
GO:0006790IEAPLAZA Homologysulfur compound metabolic processHOM03D000333
GO:0006534IEAPLAZA Homologycysteine metabolic processHOM03D000333
GO:0009069IEAPLAZA Homologyserine family amino acid metabolic processHOM03D000333
GO:0044283IEAPLAZA Homologysmall molecule biosynthetic processHOM03D000333
GO:0044281IEAPLAZA Homologysmall molecule metabolic processHOM03D000333
GO:0043436IEAPLAZA Homologyoxoacid metabolic processHOM03D000333
GO:0016053IEAPLAZA Homologyorganic acid biosynthetic processHOM03D000333
GO:0044711IEAPLAZA Homologysingle-organism biosynthetic processHOM03D000333
GO:1901564IEAPLAZA Homologyorganonitrogen compound metabolic processHOM03D000333
GO:0006520IEAPLAZA Homologycellular amino acid metabolic processHOM03D000333
GO:1901566IEAPLAZA Homologyorganonitrogen compound biosynthetic processHOM03D000333
GO:1901605IEAPLAZA Homologyalpha-amino acid metabolic processHOM03D000333
GO:0044272IEAPLAZA Homologysulfur compound biosynthetic processHOM03D000333
GO:1901607IEAPLAZA Homologyalpha-amino acid biosynthetic processHOM03D000333
GO:0008652IEAPLAZA Homologycellular amino acid biosynthetic processHOM03D000333
GO:0006082IEAPLAZA Homologyorganic acid metabolic processHOM03D000333
GO:0000096IEAPLAZA Homologysulfur amino acid metabolic processHOM03D000333
GO:0000097IEAPLAZA Homologysulfur amino acid biosynthetic processHOM03D000333
GO:0009070IEAPLAZA Homologyserine family amino acid biosynthetic processHOM03D000333
GO:0006563IEAPLAZA HomologyL-serine metabolic processHOM03D000333
GO:0046394IEAPLAZA Homologycarboxylic acid biosynthetic processHOM03D000333
GO:0019752IEAPLAZA Homologycarboxylic acid metabolic processHOM03D000333

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004124IDA, IGIIEA, UniProtcysteine synthase activity1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
GO:0005515IPIGene Ontologyprotein binding1
GO:0016740IEAUniProttransferase activity1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
GO:0016835IEAPLAZA Homologycarbon-oxygen lyase activityHOM03D000333
GO:0016829IEAPLAZA Homologylyase activityHOM03D000333

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005737ISMGene Ontologycytoplasm1
GO:0005829IDA, ISS, UniProtcytosol1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
GO:0005634IDAUniProtnucleus1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
GO:0005774IDAUniProtvacuolar membrane1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
GO:0016020IDAGene Ontologymembrane1
GO:0005886IDAUniProtplasma membrane1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
GO:0005777IDAUniProtperoxisome1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
GO:0009507IDAGene Ontologychloroplast1
GO:0048046IDAUniProtapoplast1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
GO:0009570IDAUniProtchloroplast stroma1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001926Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily
IPR001216Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site
IPR005859Cysteine synthase A
IPR005856Cysteine synthase K/M

Mapman id Description
13.1.5.3.1amino acid metabolism.synthesis.serine-glycine-cysteine group.cysteine.OASTL
No SignalP domains detected for this gene.