PLAZA 3.0 Dicots gene overview : AT4G08500

Gene: AT4G08500 (Arabidopsis thaliana)

Overview

Gene Identifier: AT4G08500
Transcript Identifier: AT4G08500.1
Gene Type: Coding gene
Location: 4 : 5404272-5407062 : negative

Family

Gene family: HOM03D000051
(1476 genes in 31 species)
specific family
Subfamily: ORTHO03D001112
(57 genes in 28 species)
specific family
Duplication type: Tandem duplicate

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Descriptions

Description: MAPK/ERK kinase kinase 1

Curated Summary: Encodes a member of the A1 subgroup of the MEKK (MAPK/ERK kinase kinase) family. MEKK is another name for Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK or MAP3K). This subgroup has four members: At4g08500 (MEKK1, also known as ARAKIN, MAP3Kb1, MAPKKK8), At4g08480 (MEKK2, also known as MAP3Kb4, MAPKKK9), At4g08470 (MEKK3, also known as MAP3Kb3, MAPKKK10) and At4g12020 (MEKK4, also known as MAP3Kb5, MAPKKK11, WRKY19). Nomenclatures for mitogen-activated protein kinases are described in Trends in Plant Science 2002, 7(7):301. Mediates cold, salt, cadmium and wounding stress signalling. Phosphorylates MEK1.

Identifiers

Identifier	Name
alias	ATMEKK1
alias	MAPK/ERK kinase kinase 1
alias	MEKK1
alias	ARAKIN
alias	MAPKKK8
uniprot	Q39008

Toolbox

Explore

...the colinearity of this gene with other genomes.
...the local gene organization for homologous genes.
...the phylogenetic tree of the homologous gene family.
...the orthologs using the Integrative Orthology Viewer.
...the conserved binding sites (upstream/downstream,intron)

View

...sequences.
...the multiple sequence alignment of the gene family with BioJS
...BLAST hits against the PLAZA database.
...BLAST hits against NCBIs protein database.
...the gene in Genomeview, a genome browser
...all colinear gene pairs.

Biological Process

GO term	Evidence(s)	Provider	Description	Source
GO:0046686	IGI	Gene Ontology	response to cadmium ion	1 AGRICOLA_IND:IND23263254
GO:0006970	IEP, IGI	Gene Ontology	response to osmotic stress	1 2
GO:0009651	IEP	UniProt	response to salt stress	1 2 3 4 5 6 7 8 9 10
GO:0009611	IDA, RCA,	UniProt	response to wounding	1 2 3 4 5 6 7 8 9 10 11
GO:0046777	IDA	UniProt	protein autophosphorylation	1 2 3 4 5 6 7 8 9 10
GO:0000165	IMP, IPI, RCA	Gene Ontology	MAPK cascade	1 2 3
GO:0006612	RCA	Gene Ontology	protein targeting to membrane	1
GO:0007154	RCA	Gene Ontology	cell communication	1
GO:0009409	IEP, RCA,	UniProt	response to cold	1 2 3 4 5 6 7 8 9 10 11
GO:0009556	RCA	Gene Ontology	microsporogenesis	1
GO:0009620	RCA	Gene Ontology	response to fungus	1
GO:0009695	RCA	Gene Ontology	jasmonic acid biosynthetic process	1
GO:0009697	RCA	Gene Ontology	salicylic acid biosynthetic process	1
GO:0009738	RCA	Gene Ontology	abscisic acid-activated signaling pathway	1
GO:0009753	RCA	Gene Ontology	response to jasmonic acid	1
GO:0009862	RCA	Gene Ontology	systemic acquired resistance, salicylic acid mediated signaling pathway	1
GO:0009863	RCA	Gene Ontology	salicylic acid mediated signaling pathway	1
GO:0009867	RCA	Gene Ontology	jasmonic acid mediated signaling pathway	1
GO:0010363	RCA	Gene Ontology	regulation of plant-type hypersensitive response	1
GO:0030968	RCA	Gene Ontology	endoplasmic reticulum unfolded protein response	1
GO:0031348	RCA	Gene Ontology	negative regulation of defense response	1
GO:0043069	RCA	Gene Ontology	negative regulation of programmed cell death	1
GO:0045087	RCA	Gene Ontology	innate immune response	1
GO:0050832	RCA	Gene Ontology	defense response to fungus	1
GO:0052543	RCA	Gene Ontology	callose deposition in cell wall	1
GO:0010449	IGI	UniProt	root meristem growth	1 2 3 4 5 6 7 8 9 10
GO:0022622	IMP	Gene Ontology	root system development	1
GO:1902065	IMP	UniProt	response to L-glutamate	1 2 3 4 5 6 7 8 9 10
GO:0006468	IEA	InterPro	protein phosphorylation
GO:0031347	ISO	PLAZA Tree-based Orthology	regulation of defense response	AT4G08480
GO:0044260	IEA	PLAZA Homology	cellular macromolecule metabolic process	HOM03D000051
GO:0006796	IEA	PLAZA Homology	phosphate-containing compound metabolic process	HOM03D000051
GO:0006793	IEA	PLAZA Homology	phosphorus metabolic process	HOM03D000051
GO:0043170	IEA	PLAZA Homology	macromolecule metabolic process	HOM03D000051
GO:0044237	IEA	PLAZA Homology	cellular metabolic process	HOM03D000051
GO:0044238	IEA	PLAZA Homology	primary metabolic process	HOM03D000051
GO:0009987	IEA	PLAZA Homology	cellular process	HOM03D000051
GO:0016310	IEA	PLAZA Homology	phosphorylation	HOM03D000051
GO:0008152	IEA	PLAZA Homology	metabolic process	HOM03D000051
GO:0043412	IEA	PLAZA Homology	macromolecule modification	HOM03D000051
GO:0071704	IEA	PLAZA Homology	organic substance metabolic process	HOM03D000051
GO:0044267	IEA	PLAZA Homology	cellular protein metabolic process	HOM03D000051
GO:0006464	IEA	PLAZA Homology	cellular protein modification process	HOM03D000051
GO:0036211	IEA	PLAZA Homology	protein modification process	HOM03D000051
GO:0019538	IEA	PLAZA Homology	protein metabolic process	HOM03D000051

Molecular Function

GO term	Evidence(s)	Provider	Description	Source
GO:0016301	ISS	Gene Ontology	kinase activity	1
GO:0004709	IDA, ISS,	UniProt	MAP kinase kinase kinase activity	1 2 3 4 5 6 7 8 9 10 11
GO:0005515	IPI	Gene Ontology	protein binding	1
GO:0003677	IDA	UniProt	DNA binding	1 2 3 4 5 6 7 8 9 10
GO:0019900	IPI	Gene Ontology	kinase binding	1
GO:0004674	IDA, IEA	Gene Ontology	protein serine/threonine kinase activity	1
GO:0004672	IEA	InterPro	protein kinase activity
GO:0005524	IEA	UniProt	ATP binding	1 2 3 4 5 6 7 8 9
GO:0016772	IEA	InterPro	transferase activity, transferring phosphorus-containing groups
GO:0032555	IEA	PLAZA Homology	purine ribonucleotide binding	HOM03D000051
GO:0043168	IEA	PLAZA Homology	anion binding	HOM03D000051
GO:0032553	IEA	PLAZA Homology	ribonucleotide binding	HOM03D000051
GO:0043167	IEA	PLAZA Homology	ion binding	HOM03D000051
GO:0035639	IEA	PLAZA Homology	purine ribonucleoside triphosphate binding	HOM03D000051
GO:0097367	IEA	PLAZA Homology	carbohydrate derivative binding	HOM03D000051
GO:0003824	IEA	PLAZA Homology	catalytic activity	HOM03D000051
GO:0032559	IEA	PLAZA Homology	adenyl ribonucleotide binding	HOM03D000051
GO:1901265	IEA	PLAZA Homology	nucleoside phosphate binding	HOM03D000051
GO:0000166	IEA	PLAZA Homology	nucleotide binding	HOM03D000051
GO:0001882	IEA	PLAZA Homology	nucleoside binding	HOM03D000051
GO:0030554	IEA	PLAZA Homology	adenyl nucleotide binding	HOM03D000051
GO:0016773	IEA	PLAZA Homology	phosphotransferase activity, alcohol group as acceptor	HOM03D000051
GO:0097159	IEA	PLAZA Homology	organic cyclic compound binding	HOM03D000051
GO:0017076	IEA	PLAZA Homology	purine nucleotide binding	HOM03D000051
GO:0036094	IEA	PLAZA Homology	small molecule binding	HOM03D000051
GO:0032549	IEA	PLAZA Homology	ribonucleoside binding	HOM03D000051
GO:1901363	IEA	PLAZA Homology	heterocyclic compound binding	HOM03D000051
GO:0005488	IEA	PLAZA Homology	binding	HOM03D000051
GO:0001883	IEA	PLAZA Homology	purine nucleoside binding	HOM03D000051
GO:0016740	IEA	PLAZA Homology	transferase activity	HOM03D000051
GO:0032550	IEA	PLAZA Homology	purine ribonucleoside binding	HOM03D000051

Cellular Component

GO term	Evidence(s)	Provider	Description	Source
GO:0005634	IDA, ISM,	UniProt	nucleus	1 2 3 4 5 6 7 8 9 10 11
GO:0009941	ISO	PLAZA Tree-based Orthology	chloroplast envelope	AT4G12020

Color Legend

Experimental Evidence

Electronic Evidence

Computational Reviewed Evidence

InterPro	Description
IPR017441	Protein kinase, ATP binding site
IPR011009	Protein kinase-like domain
IPR000719	Protein kinase domain
IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
IPR008271	Serine/threonine-protein kinase, active site

Mapman id	Description
30.6	signalling.MAP kinases

No SignalP domains detected for this gene.