Gene: AT4G08500 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
4 : 5404272-5407062 : negative


Gene family
(1476 genes in 31 species)
specific family
(57 genes in 28 species)
specific family
Duplication type
Tandem duplicate

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MAPK/ERK kinase kinase 1
Curated Summary
Encodes a member of the A1 subgroup of the MEKK (MAPK/ERK kinase kinase) family. MEKK is another name for Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK or MAP3K). This subgroup has four members: At4g08500 (MEKK1, also known as ARAKIN, MAP3Kb1, MAPKKK8), At4g08480 (MEKK2, also known as MAP3Kb4, MAPKKK9), At4g08470 (MEKK3, also known as MAP3Kb3, MAPKKK10) and At4g12020 (MEKK4, also known as MAP3Kb5, MAPKKK11, WRKY19). Nomenclatures for mitogen-activated protein kinases are described in Trends in Plant Science 2002, 7(7):301. Mediates cold, salt, cadmium and wounding stress signalling. Phosphorylates MEK1.
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Identifier Name
aliasMAPK/ERK kinase kinase 1





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0046686IGIGene Ontologyresponse to cadmium ion1 AGRICOLA_IND:IND23263254
GO:0006970IEP, IGIGene Ontologyresponse to osmotic stress1 2
GO:0009651IEPUniProtresponse to salt stress1 2 3 4 5 6 7 8 9 10
GO:0009611IDA, RCA, UniProtresponse to wounding1 2 3 4 5 6 7 8 9 10 11
GO:0046777IDAUniProtprotein autophosphorylation1 2 3 4 5 6 7 8 9 10
GO:0000165IMP, IPI, RCAGene OntologyMAPK cascade1 2 3
GO:0006612RCAGene Ontologyprotein targeting to membrane1
GO:0007154RCAGene Ontologycell communication1
GO:0009409IEP, RCA, UniProtresponse to cold1 2 3 4 5 6 7 8 9 10 11
GO:0009556RCAGene Ontologymicrosporogenesis1
GO:0009620RCAGene Ontologyresponse to fungus1
GO:0009695RCAGene Ontologyjasmonic acid biosynthetic process1
GO:0009697RCAGene Ontologysalicylic acid biosynthetic process1
GO:0009738RCAGene Ontologyabscisic acid-activated signaling pathway1
GO:0009753RCAGene Ontologyresponse to jasmonic acid1
GO:0009862RCAGene Ontologysystemic acquired resistance, salicylic acid mediated signaling pathway1
GO:0009863RCAGene Ontologysalicylic acid mediated signaling pathway1
GO:0009867RCAGene Ontologyjasmonic acid mediated signaling pathway1
GO:0010363RCAGene Ontologyregulation of plant-type hypersensitive response1
GO:0030968RCAGene Ontologyendoplasmic reticulum unfolded protein response1
GO:0031348RCAGene Ontologynegative regulation of defense response1
GO:0043069RCAGene Ontologynegative regulation of programmed cell death1
GO:0045087RCAGene Ontologyinnate immune response1
GO:0050832RCAGene Ontologydefense response to fungus1
GO:0052543RCAGene Ontologycallose deposition in cell wall1
GO:0010449IGIUniProtroot meristem growth1 2 3 4 5 6 7 8 9 10
GO:0022622IMPGene Ontologyroot system development1
GO:1902065IMPUniProtresponse to L-glutamate1 2 3 4 5 6 7 8 9 10
GO:0006468IEAInterProprotein phosphorylation
GO:0031347ISOPLAZA Tree-based Orthologyregulation of defense responseAT4G08480
GO:0044260IEAPLAZA Homologycellular macromolecule metabolic processHOM03D000051
GO:0006796IEAPLAZA Homologyphosphate-containing compound metabolic processHOM03D000051
GO:0006793IEAPLAZA Homologyphosphorus metabolic processHOM03D000051
GO:0043170IEAPLAZA Homologymacromolecule metabolic processHOM03D000051
GO:0044237IEAPLAZA Homologycellular metabolic processHOM03D000051
GO:0044238IEAPLAZA Homologyprimary metabolic processHOM03D000051
GO:0009987IEAPLAZA Homologycellular processHOM03D000051
GO:0016310IEAPLAZA HomologyphosphorylationHOM03D000051
GO:0008152IEAPLAZA Homologymetabolic processHOM03D000051
GO:0043412IEAPLAZA Homologymacromolecule modificationHOM03D000051
GO:0071704IEAPLAZA Homologyorganic substance metabolic processHOM03D000051
GO:0044267IEAPLAZA Homologycellular protein metabolic processHOM03D000051
GO:0006464IEAPLAZA Homologycellular protein modification processHOM03D000051
GO:0036211IEAPLAZA Homologyprotein modification processHOM03D000051
GO:0019538IEAPLAZA Homologyprotein metabolic processHOM03D000051

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0016301ISSGene Ontologykinase activity1
GO:0004709IDA, ISS, UniProtMAP kinase kinase kinase activity1 2 3 4 5 6 7 8 9 10 11
GO:0005515IPIGene Ontologyprotein binding1
GO:0003677IDAUniProtDNA binding1 2 3 4 5 6 7 8 9 10
GO:0019900IPIGene Ontologykinase binding1
GO:0004674IDA, IEAGene Ontologyprotein serine/threonine kinase activity1
GO:0004672IEAInterProprotein kinase activity
GO:0005524IEAUniProtATP binding1 2 3 4 5 6 7 8 9
GO:0016772IEAInterProtransferase activity, transferring phosphorus-containing groups
GO:0032555IEAPLAZA Homologypurine ribonucleotide bindingHOM03D000051
GO:0043168IEAPLAZA Homologyanion bindingHOM03D000051
GO:0032553IEAPLAZA Homologyribonucleotide bindingHOM03D000051
GO:0043167IEAPLAZA Homologyion bindingHOM03D000051
GO:0035639IEAPLAZA Homologypurine ribonucleoside triphosphate bindingHOM03D000051
GO:0097367IEAPLAZA Homologycarbohydrate derivative bindingHOM03D000051
GO:0003824IEAPLAZA Homologycatalytic activityHOM03D000051
GO:0032559IEAPLAZA Homologyadenyl ribonucleotide bindingHOM03D000051
GO:1901265IEAPLAZA Homologynucleoside phosphate bindingHOM03D000051
GO:0000166IEAPLAZA Homologynucleotide bindingHOM03D000051
GO:0001882IEAPLAZA Homologynucleoside bindingHOM03D000051
GO:0030554IEAPLAZA Homologyadenyl nucleotide bindingHOM03D000051
GO:0016773IEAPLAZA Homologyphosphotransferase activity, alcohol group as acceptorHOM03D000051
GO:0097159IEAPLAZA Homologyorganic cyclic compound bindingHOM03D000051
GO:0017076IEAPLAZA Homologypurine nucleotide bindingHOM03D000051
GO:0036094IEAPLAZA Homologysmall molecule bindingHOM03D000051
GO:0032549IEAPLAZA Homologyribonucleoside bindingHOM03D000051
GO:1901363IEAPLAZA Homologyheterocyclic compound bindingHOM03D000051
GO:0005488IEAPLAZA HomologybindingHOM03D000051
GO:0001883IEAPLAZA Homologypurine nucleoside bindingHOM03D000051
GO:0016740IEAPLAZA Homologytransferase activityHOM03D000051
GO:0032550IEAPLAZA Homologypurine ribonucleoside bindingHOM03D000051

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5 6 7 8 9 10 11
GO:0009941ISOPLAZA Tree-based Orthologychloroplast envelopeAT4G12020

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR017441Protein kinase, ATP binding site
IPR011009Protein kinase-like domain
IPR000719Protein kinase domain
IPR002290Serine/threonine- / dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site

Mapman id Description
30.6signalling.MAP kinases
No SignalP domains detected for this gene.