Gene: AT3G55360 (Arabidopsis thaliana)

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Gene Identifier
AT3G55360
Transcript Identifier
AT3G55360.1
Gene Type
Coding gene
Location
3 : 20521186-20522856 : negative

Family

Gene family
HOM03D005218
(40 genes in 29 species)
specific family

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Descriptions

Description
3-oxo-5-alpha-steroid 4-dehydrogenase family protein
Curated Summary
Enoyl-CoA reductase is involved in all very long chain fatty acids (VLCFA) elongation reactions that are required for cuticular wax, storage lipid and sphingolipid metabolism. The protein is located in the ER, but in contrast to its yeast homolog TSC13 is not particularly enriched in the nuclear envelope-vacuole junction. Mutants in this gene show abnormal organ morphology and stem glossiness. Cells in all tissues are only about 1/3 of the size of wild type cells. The morphological changes are most likely to result from the reduction in the VLCFA content of sphingolipids. Mutants also show abnormalities in the endocytic membrane organization and transport.
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Identifiers

Identifier Name
aliasECERIFERUM 10
aliasENOYL-COA REDUCTASE
aliasATTSC13
aliasCER10
aliasTSC13
aliasECR
uniprotQ9M2U2

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006665IMPUniProtsphingolipid metabolic process1 2 3 4 5 6
GO:0010025IMPUniProtwax biosynthetic process1 2 3 4 5 6
GO:0006816RCAGene Ontologycalcium ion transport1
GO:0007030RCAGene OntologyGolgi organization1
GO:0009651RCAGene Ontologyresponse to salt stress1
GO:0016126RCAGene Ontologysterol biosynthetic process1
GO:0046520RCAGene Ontologysphingoid biosynthetic process1
GO:0006629IEAInterProlipid metabolic process
GO:0006633IEAUniProtfatty acid biosynthetic process1 2 3 4 5

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003865ISSGene Ontology3-oxo-5-alpha-steroid 4-dehydrogenase activity1
GO:0019166IGIUniProttrans-2-enoyl-CoA reductase (NADPH) activity1 2 3 4 5 6
GO:0009922IMPUniProtfatty acid elongase activity1 2 3 4 5 6
GO:0016627IEAInterProoxidoreductase activity, acting on the CH-CH group of donors

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005789IDAGene Ontologyendoplasmic reticulum membrane1
GO:0009923TASUniProtfatty acid elongase complex1 2 3 4 5 6
GO:0005783IDAGene Ontologyendoplasmic reticulum1
GO:0005886IDAUniProtplasma membrane1 2 3 4 5 6
GO:0005737IEAInterProcytoplasm
GO:0016021IEAUniProtintegral to membrane1 2 3 4 5

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR0011043-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal

Mapman id Description
11.8.7lipid metabolism.exotics (steroids, squalene etc).trans-2-enoyl-CoA reductase (NADPH)
No SignalP domains detected for this gene.