Gene: AT3G50630 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT3G50630
Transcript Identifier
AT3G50630.1
Gene Type
Coding gene
Location
3 : 18800508-18801366 : positive

Family

Gene family
HOM03D010596
(6 genes in 5 species)
specific family

Loading...please wait

Descriptions

Description
KIP-related protein 2
Curated Summary
Kip-related protein (KRP) gene, encodes CDK (cyclin-dependent kinase) inhibitor (CKI), negative regulator of cell division. A member of seven KRP genes found in Arabidopsis thaliana. Differential expression patterns for distinct KRPs were revealed by in situ hybridization. Gene was isolated from a yeast two hybrid screen as an interacting protein of CDC2A. Recombinant protein has a strong kinase inhibitor activity in vitro. Transcript is expressed in all tissues examined but is differentially distributed from ICK1. Controls the onset of the endoreduplication cycle through inhibition of CDKA;1. The KRP2 protein abundance is regulated by proteolysis through CDKB1;1 phosphorylation.
Show more...

Identifiers

Identifier Name
aliasKRP2
aliasICK2
aliasKIP-related protein 2
uniprotQ9SCR2

Toolbox

Explore

View

 

Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0045736IDA, ISSRCA, UniProtnegative regulation of cyclin-dependent protein serine/threonine kinase activity1 2 3 4 5 6 7 8 9 10 11
GO:0042023IMP, RCA, UniProtDNA endoreduplication1 2 3 4 5 6 7 8 9 10
GO:0000278RCAGene Ontologymitotic cell cycle1
GO:0010440RCAGene Ontologystomatal lineage progression1
GO:0007050IEAUniProtcell cycle arrest1 2 3 4 5 6 7 8

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004861IGI, ISSIEA, UniProtcyclin-dependent protein serine/threonine kinase inhibitor activity1 2 3 4 5 6 7 8 9 10
GO:0005515IPIGene Ontologyprotein binding1
GO:0019210IDAGene Ontologykinase inhibitor activity1
GO:0030291IEAPLAZA Homologyprotein serine/threonine kinase inhibitor activityHOM03D010596

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISM, IEAGene Ontologynucleus1
GO:0005654IEAUniProtnucleoplasm1 2 3 4 5 6 7 8

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR003175Cyclin-dependent kinase inhibitor

Mapman id Description
31.3cell.cycle
No SignalP domains detected for this gene.