Gene: AT3G16950 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
3 : 5786508-5790383 : negative


Gene family
(188 genes in 31 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

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lipoamide dehydrogenase 1
Curated Summary
encodes a plastid lipoamide dehydrogenase, subunit of the pyruvate dehydrogenase complex which provides acetyl-CoA for de novo fatty acid biosynthesis. The gene is highly expressed in developing seeds.
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Identifier Name
aliaslipoamide dehydrogenase 1





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006086TASUniProtacetyl-CoA biosynthetic process from pyruvate1 2 3 4 5 6
GO:0006085RCAGene Ontologyacetyl-CoA biosynthetic process1
GO:0042744RCAGene Ontologyhydrogen peroxide catabolic process1
GO:0045454IEAUniProtcell redox homeostasis1 2 3 4 5
GO:0055114IEAInterProoxidation-reduction process
GO:0046685IMPUniProtresponse to arsenic-containing substance1 2 3 4 5
GO:0019725IEAPLAZA Homologycellular homeostasisHOM03D000742
GO:0065008IEAPLAZA Homologyregulation of biological qualityHOM03D000742
GO:0042592IEAPLAZA Homologyhomeostatic processHOM03D000742

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004148ISS, IEA, UniProtdihydrolipoyl dehydrogenase activity1 2 3 4 5 6
GO:0016668IEAInterProoxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660IEAUniProtflavin adenine dinucleotide binding1 2 3 4 5
GO:0016491IEAInterProoxidoreductase activity
GO:0016667IEAPLAZA Homologyoxidoreductase activity, acting on a sulfur group of donorsHOM03D000742
GO:0050662IEAPLAZA Homologycoenzyme bindingHOM03D000742
GO:0016651IEAPLAZA Homologyoxidoreductase activity, acting on NAD(P)HHOM03D000742

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005739ISMGene Ontologymitochondrion1
GO:0009570IDAUniProtchloroplast stroma1 2 3 4 5 6
GO:0009941IDAUniProtchloroplast envelope1 2 3 4 5 6
GO:0009507IDAGene Ontologychloroplast1
GO:0005730IDAUniProtnucleolus1 2 3 4 5 6
GO:0005829RCAGene Ontologycytosol1
GO:0044464IEAPLAZA Homologycell partHOM03D000742

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR004099Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
IPR012999Pyridine nucleotide-disulphide oxidoreductase, class I, active site
IPR013027FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR001327Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR023753Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
IPR006258Dihydrolipoamide dehydrogenase
IPR016156FAD/NAD-linked reductase, dimerisation domain

Mapman id Description / org transformation.TCA.pyruvate DH.E3
No SignalP domains detected for this gene.