Gene: AT2G47460 (Arabidopsis thaliana)

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Gene Identifier
AT2G47460
Transcript Identifier
AT2G47460.1
Gene Type
Coding gene
Location
2 : 19476438-19479242 : positive

Family

Gene family
HOM03D000008
(3494 genes in 30 species)
specific family
Subfamily
ORTHO03D046642
(3 genes in 3 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

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Descriptions

Description
myb domain protein 12
Curated Summary
'MYB12 belongs to subgroup 7 of the R2R3-MYB family. It strongly activates the promoters of chalcone synthase (CHS), flavanone 3-hydroxylase (F3H), flavonol synthase (FLS) and - to a lesser extent - chalcone flavanone isomerase (CHI), but cannot activate the promoters of flavonoid-3'hydroxylase (F3'H) and dihydroflavonol 4-reductase (DF). The activation requires a functional MYB recognition element (MRE). Results from the myb12-1f allele indicate that an activation domain might be present in the C-terminus. Overexpression or knock-out plants do not show any obvious phenotype under greenhouse conditions. Young myb12-ko seedlings contain reduced amounts of flavonoids (quercetin and kaempferol), while seedlings as well as leaves of MYB12-OX plants displayed an increased flavonoid content. They did not show any significant difference in anthocyanin content. Expression of CHS and FLS shows a clear correlation to MYB12 expression levels. CHI and F3H show increased transcript levels in the MYB12-OX lines, but no differences in the knock-out. Even in the absence of functional MYB12, flavonol biosynthesis is not completely absent, suggesting functional redundancy. ' The redundant factors are MYB11 and MYB111 although MYB12 is primarily required for flavonol biosynthesis in roots. Mutations in MYB12 block both auxin and ethylene stimulation of flavonoid synthesis.
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Identifiers

Identifier Name
aliasmyb domain protein 12
aliasATMYB12
aliasPFG1
aliasMYB12
aliasMYB DOMAIN PROTEIN 12
aliasPRODUCTION OF FLAVONOL GLYCOSIDES 1
uniprotO22264

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0009813IMP, RCA, UniProtflavonoid biosynthetic process1 2 3 4 5 6 7 8 9
GO:0045893IDAUniProtpositive regulation of transcription, DNA-dependent1 2 3 4 5 6 7 8
GO:0009723IEPUniProtresponse to ethylene1 2 3 4 5 6 7 8
GO:0009733IEPUniProtresponse to auxin1 2 3 4 5 6 7 8
GO:0009744RCAGene Ontologyresponse to sucrose1
GO:0010224RCAGene Ontologyresponse to UV-B1
GO:0006355ISSGene Ontologyregulation of transcription, DNA-dependent1
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5 6 7

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677IEA, ISSUniProtDNA binding1 2 3 4 5 6 7 8
GO:0003700ISSUniProtsequence-specific DNA binding transcription factor activity1 2 3 4 5 6 7 8
GO:0003682IEAUniProtchromatin binding1 2 3 4 5 6 7
GO:0005488IEAPLAZA HomologybindingHOM03D000008
GO:1901363IEAPLAZA Homologyheterocyclic compound bindingHOM03D000008
GO:0097159IEAPLAZA Homologyorganic cyclic compound bindingHOM03D000008
GO:0003676IEAPLAZA Homologynucleic acid bindingHOM03D000008

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IEA, ISMUniProtnucleus1 2 3 4 5 6 7 8

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR009057Homeodomain-like
IPR001005SANT/Myb domain
IPR017930Myb domain

Mapman id Description
27.3.25RNA.regulation of transcription.MYB domain transcription factor family
No SignalP domains detected for this gene.
DatabaseType
PlnTFDBMYB