Gene: AT2G46280 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT2G46280
Transcript Identifier
AT2G46280.1
Gene Type
Coding gene
Location
2 : 19003656-19005393 : negative

Family

Gene family
HOM03D001613
(101 genes in 31 species)
specific family
Subfamily
ORTHO03D001979
(45 genes in 30 species)
specific family
Duplication type
Tandem duplicate

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Descriptions

Description
TGF-beta receptor interacting protein 1
Curated Summary
Encodes a homolog of mammalian TGF-beta receptor interacting protein. Co-immunoprecipitates with BRI1 and can be phosphorylated in vitro by BRI1 at specific sites (Thr-14, Thr-89, and either Thr-197 or Ser-198). May therefore be a cytoplasmic BRI1 substrate and involved in brassinosteroid regulated plant growth and development.The encoded protein has two DWD motifs. It can bind to DDB1a in Y2H assays, and DDB1b in co-IP assays, and may be involved in the formation of a CUL4-based E3 ubiquitin ligase
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Identifiers

Identifier Name
aliasTGF-beta receptor interacting protein 1
aliasTRIP-1
aliasTRIP1
aliasTIF3I1
uniprotQ38884

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0046686IEPUniProtresponse to cadmium ion1 2 3 4 5
GO:0009651IEPUniProtresponse to salt stress1 2 3 4 5
GO:0001731IEAUniProtformation of translation preinitiation complex1 2 3 4
GO:0006446IEAUniProtregulation of translational initiation1 2 3 4

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0000166ISSGene Ontologynucleotide binding1
GO:0005515IPI, IEAGene Ontologyprotein binding1
GO:0003743IEAUniProttranslation initiation factor activity1 2 3 4

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005737ISM, IEAGene Ontologycytoplasm1
GO:0080008IPIUniProtCul4-RING ubiquitin ligase complex1 2 3 4 5
GO:0005829IDAUniProtcytosol1 2 3 4 5
GO:0005852IEAUniProteukaryotic translation initiation factor 3 complex1 2 3 4
GO:0016282IEAUniProteukaryotic 43S preinitiation complex1 2 3 4
GO:0033290IEAUniProteukaryotic 48S preinitiation complex1 2 3 4
GO:0009506ISOPLAZA Tree-based OrthologyplasmodesmaAT2G46290

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR017986WD40-repeat-containing domain
IPR001680WD40 repeat
IPR027525Eukaryotic translation initiation factor 3 subunit I
IPR020472G-protein beta WD-40 repeat
IPR019775WD40 repeat, conserved site
IPR015943WD40/YVTN repeat-like-containing domain

Mapman id Description
17.3.2.99hormone metabolism.brassinosteroid.signal transduction.other
No SignalP domains detected for this gene.