Gene: AT2G45140 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT2G45140
Transcript Identifier
AT2G45140.1
Gene Type
Coding gene
Location
2 : 18611029-18612971 : positive

Family

Gene family
HOM03D000480
(267 genes in 31 species)
specific family
Subfamily
ORTHO03D006780
(32 genes in 23 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
plant VAP homolog 12
Curated Summary
Encodes a Plant VAMP-Associated protein that localizes to the ER and binds to the sitosterol-binding protein ORP3a. The WFDE motif in ORP3a appears to be important for this direct interaction. Mutation of this motif causes ORP3a to relocalize to the Golgi and cytosol. The interaction between PVA12 and ORP3a does not appear to be sterol-dependent.
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Identifiers

Identifier Name
aliasPVA12
aliasplant VAP homolog 12
uniprotQ9SHC8

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006605IDAUniProtprotein targeting1 2 3 4 5 6 7 8 9
GO:0030968RCAGene Ontologyendoplasmic reticulum unfolded protein response1
GO:0046482RCAGene Ontologypara-aminobenzoic acid metabolic process1
GO:0046777RCAGene Ontologyprotein autophosphorylation1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005198IEA, ISSUniProtstructural molecule activity1 2 3 4 5 6 7 8 9
GO:0005515IPIGene Ontologyprotein binding1

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005886IDAUniProtplasma membrane1 2 3 4 5 6 7 8 9
GO:0005783IDAUniProtendoplasmic reticulum1 2 3 4 5 6 7 8 9
GO:0005634IDAUniProtnucleus1 2 3 4 5 6 7 8 9
GO:0005829IDAUniProtcytosol1 2 3 4 5 6 7 8 9
GO:0005789IEAUniProtendoplasmic reticulum membrane1 2 3 4 5 6 7 8
GO:0016021IEAUniProtintegral to membrane1 2 3 4 5 6 7 8
GO:0000326ISOPLAZA Tree-based Orthologyprotein storage vacuoleAT3G60600

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR008962PapD-like
IPR000535MSP domain

Mapman id Description
29.3.4.1protein.targeting.secretory pathway.ER
No SignalP domains detected for this gene.