Gene: AT2G43010 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
2 : 17887003-17888823 : positive


Gene family
(1586 genes in 29 species)
specific family
(28 genes in 20 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

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phytochrome interacting factor 4
Curated Summary
Isolated as a semidominant mutation defective in red -light responses. Encodes a nuclear localized bHLH protein that interacts with active PhyB protein. Negatively regulates phyB mediated red light responses. Involved in shade avoidance response. Protein abundance is negatively regulated by PhyB.
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Identifier Name
aliasphytochrome interacting factor 4





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0010017IMP, RCAGene Ontologyred or far-red light signaling pathway1 2
GO:0010161IGIUniProtred light signaling pathway1 2 3 4 5 6 7 8 9
GO:0009704IMPUniProtde-etiolation1 2 3 4 5 6 7 8 9
GO:0010600IDAUniProtregulation of auxin biosynthetic process1 2 3 4 5 6 7 8 9
GO:0010928IDAUniProtregulation of auxin mediated signaling pathway1 2 3 4 5 6 7 8 9
GO:0000165RCAGene OntologyMAPK cascade1
GO:0006355RCAGene Ontologyregulation of transcription, DNA-dependent1
GO:0006612RCAGene Ontologyprotein targeting to membrane1
GO:0007623RCAGene Ontologycircadian rhythm1
GO:0009617RCAGene Ontologyresponse to bacterium1
GO:0009630RCAGene Ontologygravitropism1
GO:0009862RCAGene Ontologysystemic acquired resistance, salicylic acid mediated signaling pathway1
GO:0009867RCAGene Ontologyjasmonic acid mediated signaling pathway1
GO:0010310RCAGene Ontologyregulation of hydrogen peroxide metabolic process1
GO:0010363RCAGene Ontologyregulation of plant-type hypersensitive response1
GO:0030003RCAGene Ontologycellular cation homeostasis1
GO:0031348RCAGene Ontologynegative regulation of defense response1
GO:0035304RCAGene Ontologyregulation of protein dephosphorylation1
GO:0009585IEAUniProtred, far-red light phototransduction1 2 3 4 5 6 7 8
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5 6 7 8
GO:0009693ISOPLAZA Tree-based Orthologyethylene biosynthetic processAT3G59060

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677IDA, ISS, UniProtDNA binding1 2 3 4 5 6 7 8 9 10
GO:0003700ISSUniProtsequence-specific DNA binding transcription factor activity1 2 3 4 5 6 7 8 9
GO:0005515IPIGene Ontologyprotein binding1
GO:0046983IEAInterProprotein dimerization activity
GO:0005488IEAPLAZA HomologybindingHOM03D000046

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5 6 7 8 9 10

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR011598Myc-type, basic helix-loop-helix (bHLH) domain

Mapman id Description
No SignalP domains detected for this gene.

Binding sites bound by this Transcription Factor

Binding siteNameDescriptionCounts
Motif_179CACGTGMOTIF;BES1;PIF4;PIF5Phytochrome interacting factors 4 and 5 control seedling growth in changing light conditions by directly controlling auxin signaling;A brassinosteroid transcriptional network revealed by genome-wide identification of BESI target genes in Arabidopsis thaliana; CACGTG motif; G-box; Binding site of Arabidopsis GBF4; C. roseus G-box binding factor 1 (CrGBF1) and 1 (CrGBF2) can act as transcriptional repressors of the Str promoter via direct interaction with the G-box; Essential for expression of beta-phaseolin gene during embryogenesis in bean, tobacco, Arabidopsis; Tomato Pti4 (ERF) regulates defense-related gene expression via GCC box and non-GCC box cis-element (Myb1 (GTTAGTT) and G-box (CACGTG)); Isolation and characterization of a fourth Arabidopsis thaliana G-box-binding factor, which has similarities to Fos oncoprotein; Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses11924 genes in 10 species
Motif_447AtMYC2 BS in RD22;PIF4Binding site for MYC (rd22BP1) in Arabidopsis dehydration-resposive gene, rd22; MYC binding site in rd22 gene of Arabidopsis thaliana; ABA-induction; Located at ca. -200 of rd22 gene; Also MYB at ca. -141 of rd22 gene; See also MYBATRD22; Role of Arabidopsis MYC and MYB homologs in drought- and abscisic acid-regulated gene expression. Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses10625 genes in 10 species
Matrix_7PIF4Not available5770 genes in 10 species
Matrix_108PIF4Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses3796 genes in 10 species
Matrix_305PIF4Interaction between BZR1 and PIF4 integrates brassinosteroid and environmental responses1553 genes in 10 species

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