Gene: AT2G38440 (Arabidopsis thaliana)

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Gene Identifier
AT2G38440
Transcript Identifier
AT2G38440.1
Gene Type
Coding gene
Location
2 : 16095550-16100851 : positive

Family

Gene family
HOM03D001534
(105 genes in 29 species)
specific family
Subfamily
ORTHO03D003778
(37 genes in 29 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
SCAR homolog 2
Curated Summary
Encodes a subunit of the WAVE complex. The WAVE complex is required for activation of ARP2/3 complex which functions in actin microfilament nucleation and branching. Mutations cause defects in both the actin and microtubule cytoskeletons that result in aberrant epidermal cell expansion. itb1 mutants showed irregularities in trichome branch positioning and expansion. The SHD domain of this protein binds to BRK1 and overexpression of the SHD domain results in a dominant negative phenotype.
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Identifiers

Identifier Name
aliasATSCAR2
aliasITB1
aliasIRREGULAR TRICHOME BRANCH1
aliasWAVE4
aliasSCAR homolog 2
aliasDIS3
aliasSCAR2
aliasSCAR HOMOLOG 2
uniprotQ5XPJ9

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0010090IMP, RCA, TASGene Ontologytrichome morphogenesis1 2 3
GO:0045010TAS, RCAUniProtactin nucleation1 2 3 4 5 6 7 8 9
GO:0016337IMPUniProtcell-cell adhesion1 2 3 4 5 6 7 8
GO:0051127IMP, ISS, UniProtpositive regulation of actin nucleation1 2 3 4 5 6 7 8 9
GO:0010091IMPUniProttrichome branching1 2 3 4 5 6 7 8
GO:0030036IMP, IEAGene Ontologyactin cytoskeleton organization1
GO:0000003RCAGene Ontologyreproduction1
GO:0000278RCAGene Ontologymitotic cell cycle1
GO:0003002RCAGene Ontologyregionalization1
GO:0006325RCAGene Ontologychromatin organization1
GO:0007131RCAGene Ontologyreciprocal meiotic recombination1
GO:0007155RCAGene Ontologycell adhesion1
GO:0009887RCAGene Ontologyorgan morphogenesis1
GO:0009888RCAGene Ontologytissue development1
GO:0009965RCAGene Ontologyleaf morphogenesis1
GO:0010014RCAGene Ontologymeristem initiation1
GO:0010638RCAGene Ontologypositive regulation of organelle organization1
GO:0016049RCAGene Ontologycell growth1
GO:0033043RCAGene Ontologyregulation of organelle organization1
GO:0033044RCAGene Ontologyregulation of chromosome organization1
GO:0045595RCAGene Ontologyregulation of cell differentiation1
GO:0048449RCAGene Ontologyfloral organ formation1
GO:0048589RCAGene Ontologydevelopmental growth1
GO:0048765RCAGene Ontologyroot hair cell differentiation1
GO:0071555RCAGene Ontologycell wall organization1

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515IPIGene Ontologyprotein binding1
GO:0003779IEAInterProactin binding

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005737IDA, ISMGene Ontologycytoplasm1 2
GO:0031209ISS, TAS, UniProtSCAR complex1 2 3 4 5 6 7 8 9
GO:0005886IDAUniProtplasma membrane1 2 3 4 5 6 7 8
GO:0005856IEAUniProtcytoskeleton1 2 3 4 5 6 7

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR028288SCAR/WAVE family
IPR003124WH2 domain

Mapman id Description
31.1cell.organisation
No SignalP domains detected for this gene.