Gene: AT2G36490 (Arabidopsis thaliana)

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Gene Identifier
AT2G36490
Transcript Identifier
AT2G36490.1
Gene Type
Coding gene
Location
2 : 15308259-15314272 : negative

Family

Gene family
HOM03D000874
(165 genes in 31 species)
specific family
Subfamily
ORTHO03D017502
(9 genes in 7 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
demeter-like 1
Curated Summary
A repressor of transcriptional gene silencing. Functions by demethylating the target promoter DNA. Interacts physically with RPA2/ROR1. In the ros1 mutants, an increase in methylation is observed in a number of gene promoters. Among the loci affected by ros1, a few (RD29A and At1g76930) are affected in cytosine methylation in all sequence contexts (CpG, CpNpG or CpNpN), although many others are affected primarily in non-CpG contexts.
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Identifiers

Identifier Name
aliasREPRESSOR OF SILENCING1
aliasROS1
aliasDML1
aliasdemeter-like 1
uniprotQ9SJQ6

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006281IMP, IEA, UniProtDNA repair1 2 3 4 5 6 7 8 9 10 11 12
GO:0006342IMPUniProtchromatin silencing1 2 3 4 5 6 7 8 9 10 11 12
GO:0006306IDA, RCA, UniProtDNA methylation1 2 3 4 5 6 7 8 9 10 11 12 13
GO:0031936IMPUniProtnegative regulation of chromatin silencing1 2 3 4 5 6 7 8 9 10 11 12
GO:0080111IMPUniProtDNA demethylation1 2 3 4 5 6 7 8 9 10 11 12
GO:0006284IEAUniProtbase-excision repair1 2 3 4 5 6 7 8 9 10 11
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5 6 7 8 9 10 11
GO:0006349ISOPLAZA Tree-based Orthologyregulation of gene expression by genetic imprintingAT5G04560
GO:0009793ISOPLAZA Tree-based Orthologyembryo development ending in seed dormancyAT5G04560

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003906IDA, ISS, UniProtDNA-(apurinic or apyrimidinic site) lyase activity1 2 3 4 5 6 7 8 9 10 11 12 13
GO:0019104IDA, ISSTAS, UniProtDNA N-glycosylase activity1 2 3 4 5 6 7 8 9 10 11 12 13 14
GO:0005515IPIGene Ontologyprotein binding1
GO:0051539IEAUniProt4 iron, 4 sulfur cluster binding1 2 3 4 5 6 7 8 9 10 11
GO:0003824IEAInterProcatalytic activity
GO:0003677IEAUniProtDNA binding1 2 3 4 5 6 7 8 9 10 11
GO:0046872IEAUniProtmetal ion binding1 2 3 4 5 6 7 8 9 10 11

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634IDA, ISM, UniProtnucleus1 2 3 4 5 6 7 8 9 10 11 12 13
GO:0043078ISOPLAZA Tree-based Orthologypolar nucleusAT5G04560

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR011257DNA glycosylase
IPR003265HhH-GPD domain
IPR023170Helix-turn-helix, base-excision DNA repair, C-terminal
IPR003651Endonuclease III-like, iron-sulphur cluster loop motif

Mapman id Description
28.2DNA.repair
No SignalP domains detected for this gene.