Gene: AT2G18915 (Arabidopsis thaliana)

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Gene Identifier
AT2G18915
Transcript Identifier
AT2G18915.2
Gene Type
Coding gene
Location
2 : 8194792-8197255 : negative

Family

Gene family
HOM03D001980
(86 genes in 29 species)
specific family
Subfamily
ORTHO03D001218
(55 genes in 24 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
LOV KELCH protein 2
Curated Summary
encodes a member of F-box proteins that includes two other proteins in Arabidopsis (ZTL and FKF1). These proteins contain a unique structure containing a PAS domain at their N-terminus, an F-box motif, and 6 kelch repeats at their C-terminus. Overexpression results in arrhythmic phenotypes for a number of circadian clock outputs in both constant light and constant darkness, long hypocotyls under multiple fluences of both red and blue light, and a loss of photoperiodic control of flowering time. Although this the expression of this gene itself is not regulated by circadian clock, it physically interacts with Dof transcription factors that are transcriptionally regulated by circadian rhythm. LKP2 interacts with Di19, CO/COL family proteins.
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Identifiers

Identifier Name
aliasLOV KELCH protein 2
aliasADAGIO 2
aliasLKP2
aliasADO2
uniprotQ8W420

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0007623ISSGene Ontologycircadian rhythm1
GO:0006511TASGene Ontologyubiquitin-dependent protein catabolic process1
GO:0042752IMP, RCA, UniProtregulation of circadian rhythm1 2 3 4 5 6 7 8 9 10 11 12
GO:0006869RCAGene Ontologylipid transport1
GO:0009639RCAGene Ontologyresponse to red or far red light1
GO:0048574RCAGene Ontologylong-day photoperiodism, flowering1
GO:0007165IEAInterProsignal transduction
GO:0009908IEAUniProtflower development1 2 3 4 5 6 7 8 9 10
GO:0016567IEAUniProtprotein ubiquitination1 2 3 4 5 6 7 8 9 10
GO:0018298IEAUniProtprotein-chromophore linkage1 2 3 4 5 6 7 8 9 10
GO:0048511IEAUniProtrhythmic process1 2 3 4 5 6 7 8 9 10
GO:0010114ISOPLAZA Integrative Orthologyresponse to red lightAT5G57360
GO:0031146ISOPLAZA Integrative OrthologySCF-dependent proteasomal ubiquitin-dependent protein catabolic processAT5G57360
GO:0010498ISOPLAZA Integrative Orthologyproteasomal protein catabolic processAT5G57360
GO:0043153ISOPLAZA Integrative Orthologyentrainment of circadian clock by photoperiodAT5G57360
GO:0010468ISOPLAZA Integrative Orthologyregulation of gene expressionAT1G68050
GO:0009637ISOPLAZA Integrative Orthologyresponse to blue lightAT1G68050
GO:0009911ISOPLAZA Integrative Orthologypositive regulation of flower developmentAT1G68050
GO:0006355ISOPLAZA Integrative Orthologyregulation of transcription, DNA-dependentAT1G68050

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004842ISSGene Ontologyubiquitin-protein ligase activity1
GO:0005515IPI, IEAGene Ontologyprotein binding1
GO:0004871IEAInterProsignal transducer activity
GO:0009881IEAUniProtphotoreceptor activity1 2 3 4 5 6 7 8 9 10
GO:0009882ISOPLAZA Integrative Orthologyblue light photoreceptor activityAT5G57360
GO:0001047ISOPLAZA Integrative Orthologycore promoter bindingAT1G68050

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISMGene Ontologynucleus1
GO:0005829IDAUniProtcytosol1 2 3 4 5 6 7 8 9 10 11
GO:0015030IDAUniProtCajal body1 2 3 4 5 6 7 8 9 10 11
GO:0019005ISOPLAZA Integrative OrthologySCF ubiquitin ligase complexAT5G57360

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000014PAS domain
IPR015915Kelch-type beta propeller
IPR011498Kelch repeat type 2
IPR001810F-box domain

Mapman id Description
29.5.11.4.3.2protein.degradation.ubiquitin.E3.SCF.FBOX
No SignalP domains detected for this gene.