Gene: AT1G76490 (Arabidopsis thaliana)

Overview top

Gene Identifier
AT1G76490
Transcript Identifier
AT1G76490.1
Gene Type
Coding gene
Location
1 : 28695801-28698206 : positive

Family

Gene family
HOM03D001017
(146 genes in 28 species)
specific family
Subfamily
ORTHO03D000262
(113 genes in 27 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
hydroxy methylglutaryl CoA reductase 1
Curated Summary
Encodes a 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is involved in melavonate biosynthesis and performs the first committed step in isoprenoid biosynthesis. Expression is activated in dark in leaf tissue but not controlled by light in the root (confine
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Identifiers

Identifier Name
aliashydroxy methylglutaryl CoA reductase 1
aliasHMGR1
aliasMAD3
aliasHMG1
aliasmiRNA action deficient 3
alias3-HYDROXY-3-METHYLGLUTARYL COA REDUCTASE 1
aliasAtHMGR1
uniprotP14891

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0016126IMPUniProtsterol biosynthetic process1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
GO:0019287IDAUniProtisopentenyl diphosphate biosynthetic process, mevalonate pathway1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
GO:0060964IMPUniProtregulation of gene silencing by miRNA1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
GO:0006816RCAGene Ontologycalcium ion transport1
GO:0007030RCAGene OntologyGolgi organization1
GO:0007033RCAGene Ontologyvacuole organization1
GO:0009611RCAGene Ontologyresponse to wounding1
GO:0009651RCAGene Ontologyresponse to salt stress1
GO:0009805RCAGene Ontologycoumarin biosynthetic process1
GO:0008299IEA, ISS, TASUniProtisoprenoid biosynthetic process1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19
GO:0009555IMPGene Ontologypollen development1
GO:0048235IMPGene Ontologypollen sperm cell differentiation1
GO:0015936IEAUniProtcoenzyme A metabolic process1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
GO:0055114IEAInterProoxidation-reduction process
GO:0034032IEAPLAZA Homologypurine nucleoside bisphosphate metabolic processHOM03D001017
GO:0051186IEAPLAZA Homologycofactor metabolic processHOM03D001017
GO:0033865IEAPLAZA Homologynucleoside bisphosphate metabolic processHOM03D001017
GO:0006732IEAPLAZA Homologycoenzyme metabolic processHOM03D001017
GO:0033875IEAPLAZA Homologyribonucleoside bisphosphate metabolic processHOM03D001017

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515IPIGene Ontologyprotein binding1
GO:0042282IDA, IGIISS, UniProthydroxymethylglutaryl-CoA reductase activity1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
GO:0050661IEAUniProtNADP binding1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
GO:0050662IEAInterProcoenzyme binding
GO:0004420IEAUniProthydroxymethylglutaryl-CoA reductase (NADPH) activity1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
GO:0016616IEAInterProoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016614IEAPLAZA Homologyoxidoreductase activity, acting on CH-OH group of donorsHOM03D001017

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005777IDAGene Ontologyperoxisome1
GO:0009536IDAGene Ontologyplastid1
GO:0005789IDAUniProtendoplasmic reticulum membrane1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
GO:0016020TASGene Ontologymembrane1
GO:0005783IDAGene Ontologyendoplasmic reticulum1
GO:0016021IEAUniProtintegral to membrane1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR023076Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
IPR023282Hydroxymethylglutaryl-CoA reductase, N-terminal
IPR002202Hydroxymethylglutaryl-CoA reductase, class I/II
IPR009023Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding
IPR009029Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding
IPR023074Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain
IPR004554Hydroxymethylglutaryl-CoA reductase, eukaryotic/arcaheal type

Mapman id Description
16.1.2.3secondary metabolism.isoprenoids.mevalonate pathway.HMG-CoA reductase
No SignalP domains detected for this gene.