Gene: AT1G59750 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
1 : 21980414-21984193 : positive


Gene family
(809 genes in 30 species)
specific family
(102 genes in 28 species)
specific family
Duplication type
Block duplicate

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auxin response factor 1
Curated Summary
Encodes a member of the auxin response factor family. ARFs bind to the cis element 5'-TGTCTC-3' ARFs mediate changes in gene expression in response to auxin. ARF's form heterodimers with IAA/AUX genes. ARF1 enhances mutant phenotypes of ARF2 and may act with ARF2 to control aspects of maturation and senescence.ARF1:LUC and 3xHA:ARF1 proteins have a half-life of ~3-4 hours and their degradation is reduced by proteasome inhibitors. 3xHA:ARF1 degradation is not affected by a pre-treatment with IAA. A nuclear-targeted fusion protein containing the middle region of ARF1 linked to LUC:NLS has a similar half-life to the full-length ARF1:LUC construct. The degradation of 3xHA:ARF1 is not affected in an axr6-3 mutant grown at room temperature, although the degradation of AXR2/IAA7 is slowed under these conditions.
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Identifier Name
aliasauxin response factor 1





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0010150IGIUniProtleaf senescence1 2 3 4 5 6 7 8 9
GO:0045892IEPUniProtnegative regulation of transcription, DNA-dependent1 2 3 4 5 6 7 8 9
GO:0006306RCAGene OntologyDNA methylation1
GO:0006342RCAGene Ontologychromatin silencing1
GO:0006346RCAGene Ontologymethylation-dependent chromatin silencing1
GO:0007267RCAGene Ontologycell-cell signaling1
GO:0009616RCAGene Ontologyvirus induced gene silencing1
GO:0010267RCAGene Ontologyproduction of ta-siRNAs involved in RNA interference1
GO:0016246RCAGene OntologyRNA interference1
GO:0035196RCAGene Ontologyproduction of miRNAs involved in gene silencing by miRNA1
GO:0006355TAS, IEAGene Ontologyregulation of transcription, DNA-dependent1
GO:0009733IEPUniProtresponse to auxin1 2 3 4 5 6 7 8 9
GO:0009725IEAInterProresponse to hormone
GO:0009734IEAUniProtauxin mediated signaling pathway1 2 3 4 5 6 7 8
GO:0006351IEAUniProttranscription, DNA-templated1 2 3 4 5 6 7 8
GO:0010468IEAPLAZA Homologyregulation of gene expressionHOM03D000119
GO:0010467IEAPLAZA Homologygene expressionHOM03D000119
GO:0006807IEAPLAZA Homologynitrogen compound metabolic processHOM03D000119
GO:0051252IEAPLAZA Homologyregulation of RNA metabolic processHOM03D000119
GO:0051171IEAPLAZA Homologyregulation of nitrogen compound metabolic processHOM03D000119
GO:0044260IEAPLAZA Homologycellular macromolecule metabolic processHOM03D000119
GO:0019222IEAPLAZA Homologyregulation of metabolic processHOM03D000119
GO:0042221IEAPLAZA Homologyresponse to chemicalHOM03D000119
GO:0019219IEAPLAZA Homologyregulation of nucleobase-containing compound metabolic processHOM03D000119
GO:0034641IEAPLAZA Homologycellular nitrogen compound metabolic processHOM03D000119
GO:0034645IEAPLAZA Homologycellular macromolecule biosynthetic processHOM03D000119
GO:0050789IEAPLAZA Homologyregulation of biological processHOM03D000119
GO:0009889IEAPLAZA Homologyregulation of biosynthetic processHOM03D000119
GO:0018130IEAPLAZA Homologyheterocycle biosynthetic processHOM03D000119
GO:0043170IEAPLAZA Homologymacromolecule metabolic processHOM03D000119
GO:0019438IEAPLAZA Homologyaromatic compound biosynthetic processHOM03D000119
GO:0046483IEAPLAZA Homologyheterocycle metabolic processHOM03D000119
GO:0016070IEAPLAZA HomologyRNA metabolic processHOM03D000119
GO:0009987IEAPLAZA Homologycellular processHOM03D000119
GO:0044271IEAPLAZA Homologycellular nitrogen compound biosynthetic processHOM03D000119
GO:0065007IEAPLAZA Homologybiological regulationHOM03D000119
GO:0010556IEAPLAZA Homologyregulation of macromolecule biosynthetic processHOM03D000119
GO:0006139IEAPLAZA Homologynucleobase-containing compound metabolic processHOM03D000119
GO:0032774IEAPLAZA HomologyRNA biosynthetic processHOM03D000119
GO:0009719IEAPLAZA Homologyresponse to endogenous stimulusHOM03D000119
GO:0006725IEAPLAZA Homologycellular aromatic compound metabolic processHOM03D000119
GO:1901576IEAPLAZA Homologyorganic substance biosynthetic processHOM03D000119
GO:0090304IEAPLAZA Homologynucleic acid metabolic processHOM03D000119
GO:0080090IEAPLAZA Homologyregulation of primary metabolic processHOM03D000119
GO:2001141IEAPLAZA Homologyregulation of RNA biosynthetic processHOM03D000119
GO:0044237IEAPLAZA Homologycellular metabolic processHOM03D000119
GO:0044238IEAPLAZA Homologyprimary metabolic processHOM03D000119
GO:0010033IEAPLAZA Homologyresponse to organic substanceHOM03D000119
GO:0009058IEAPLAZA Homologybiosynthetic processHOM03D000119
GO:0009059IEAPLAZA Homologymacromolecule biosynthetic processHOM03D000119
GO:0060255IEAPLAZA Homologyregulation of macromolecule metabolic processHOM03D000119
GO:2000112IEAPLAZA Homologyregulation of cellular macromolecule biosynthetic processHOM03D000119
GO:0031323IEAPLAZA Homologyregulation of cellular metabolic processHOM03D000119
GO:0031326IEAPLAZA Homologyregulation of cellular biosynthetic processHOM03D000119
GO:1901360IEAPLAZA Homologyorganic cyclic compound metabolic processHOM03D000119
GO:1901362IEAPLAZA Homologyorganic cyclic compound biosynthetic processHOM03D000119
GO:0034654IEAPLAZA Homologynucleobase-containing compound biosynthetic processHOM03D000119
GO:0050794IEAPLAZA Homologyregulation of cellular processHOM03D000119
GO:0008152IEAPLAZA Homologymetabolic processHOM03D000119
GO:0071704IEAPLAZA Homologyorganic substance metabolic processHOM03D000119
GO:0044249IEAPLAZA Homologycellular biosynthetic processHOM03D000119
GO:0050896IEAPLAZA Homologyresponse to stimulusHOM03D000119

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0003677IDA, IPIIEA, UniProtDNA binding1 2 3 4 5 6 7 8 9 10
GO:0003700ISS, TAS, UniProtsequence-specific DNA binding transcription factor activity1 2 3 4 5 6 7 8 9 10
GO:0005515IPIGene Ontologyprotein binding1
GO:0046983IEAInterProprotein dimerization activity
GO:0097159IEAPLAZA Homologyorganic cyclic compound bindingHOM03D000119
GO:0003676IEAPLAZA Homologynucleic acid bindingHOM03D000119
GO:1901363IEAPLAZA Homologyheterocyclic compound bindingHOM03D000119

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISS, ISM, IEA, UniProtnucleus1 2 3 4 5 6 7 8 9 10
GO:0043231IEAPLAZA Homologyintracellular membrane-bounded organelleHOM03D000119
GO:0005622IEAPLAZA HomologyintracellularHOM03D000119
GO:0043226IEAPLAZA HomologyorganelleHOM03D000119
GO:0043227IEAPLAZA Homologymembrane-bounded organelleHOM03D000119
GO:0043229IEAPLAZA Homologyintracellular organelleHOM03D000119
GO:0044464IEAPLAZA Homologycell partHOM03D000119
GO:0044424IEAPLAZA Homologyintracellular partHOM03D000119
GO:0005623IEAPLAZA HomologycellHOM03D000119

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR003311AUX/IAA protein
IPR003340B3 DNA binding domain
IPR015300DNA-binding pseudobarrel domain
IPR010525Auxin response factor

Mapman id Description
27.3.4RNA.regulation of transcription.ARF, Auxin Response Factor family
No SignalP domains detected for this gene.

Binding sites bound by this Transcription Factor

Binding siteNameDescriptionCounts
Motif_365ARF1 binding site motifARF (auxin response factor) binding site found in the promoters of primary/early auxin response genes of Arabidopsis thaliana; AuxRE;Binding site of Arabidopsis ARF1 (Auxin response factor1); Sequence found in NDE element in Soybean SAUR (Small Auxin-Up RNA) 15A gene promoter;Found in D1 or D4 element in Soybean GH3 promoter; This element was enriched in the 5'-flanking region of genes up-regulated by both IAA and BL;Dimerization and DNA binding of auxin response factors10541 genes in 10 species
Matrix_215ARF1ARF1, a transcription factor that binds to auxin response elements1142 genes in 10 species

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