Gene: AT1G50240 (Arabidopsis thaliana)

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Gene Identifier
Transcript Identifier
Gene Type
Coding gene
1 : 18607063-18614094 : positive


Gene family
(43 genes in 28 species)
specific family

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Protein kinase family protein with ARM repeat domain
Curated Summary
The FUSED (FU) gene belongs to Ser/Thr protein kinase family and has a key role in the hedgehog signaling pathway known to control cell proliferation and patterning in fruit flies and humans . Arabidopsis thaliana genome has a single Fu gene. Cytokinesis-defective mutants, which we named two-in-one (tio), result from mutations in Arabidopsis Fu. Phenotypic analysis of tio mutants reveals an essential role for TIO in conventional modes of cytokinesis in plant meristems and during male gametogenesis. TIO is tightly localized to the midline of the nascent phragmoplast and remains associated with the expanding phragmoplast ring. This gene was previously annotated as two gene models, AT1G50230.1 and AT1G50240.1, however the experimental evidence exists (Oh et al, Current Biology, 2005) showing that these two models are in fact single gene, named FUSED.
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Identifier Name





Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0000911IMP, RCA, UniProtcytokinesis by cell plate formation1 2 3 4 5
GO:0009558IMPUniProtembryo sac cellularization1 2 3 4
GO:0000226RCAGene Ontologymicrotubule cytoskeleton organization1
GO:0000278RCAGene Ontologymitotic cell cycle1
GO:0000280RCAGene Ontologynuclear division1
GO:0006260RCAGene OntologyDNA replication1
GO:0006270RCAGene OntologyDNA replication initiation1
GO:0006275RCAGene Ontologyregulation of DNA replication1
GO:0006306RCAGene OntologyDNA methylation1
GO:0006342RCAGene Ontologychromatin silencing1
GO:0006346RCAGene Ontologymethylation-dependent chromatin silencing1
GO:0007000RCAGene Ontologynucleolus organization1
GO:0008283RCAGene Ontologycell proliferation1
GO:0009909RCAGene Ontologyregulation of flower development1
GO:0010389RCAGene Ontologyregulation of G2/M transition of mitotic cell cycle1
GO:0016458RCAGene Ontologygene silencing1
GO:0016572RCAGene Ontologyhistone phosphorylation1
GO:0031047RCAGene Ontologygene silencing by RNA1
GO:0031048RCAGene Ontologychromatin silencing by small RNA1
GO:0034968RCAGene Ontologyhistone lysine methylation1
GO:0042023RCAGene OntologyDNA endoreduplication1
GO:0042127RCAGene Ontologyregulation of cell proliferation1
GO:0051225RCAGene Ontologyspindle assembly1
GO:0051567RCAGene Ontologyhistone H3-K9 methylation1
GO:0051726RCAGene Ontologyregulation of cell cycle1
GO:0006468IEAInterProprotein phosphorylation

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004674IEA, ISSUniProtprotein serine/threonine kinase activity1 2 3 4
GO:0005515IPI, IEAGene Ontologyprotein binding1
GO:0004672IEAInterProprotein kinase activity
GO:0005524IEAUniProtATP binding1 2 3
GO:0016772IEAInterProtransferase activity, transferring phosphorus-containing groups

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005737ISMGene Ontologycytoplasm1
GO:0009524IDAUniProtphragmoplast1 2 3 4
GO:0005856IEAUniProtcytoskeleton1 2 3

Color Legend

Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR017441Protein kinase, ATP binding site
IPR000719Protein kinase domain
IPR016024Armadillo-type fold
IPR011989Armadillo-like helical
IPR002290Serine/threonine- / dual specificity protein kinase, catalytic domain
IPR008271Serine/threonine-protein kinase, active site
IPR011009Protein kinase-like domain

Mapman id Description
35.1.3not ontology.armadillo/beta-catenin repeat family protein
No SignalP domains detected for this gene.