Gene: AT1G48050 (Arabidopsis thaliana)

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Gene Identifier
AT1G48050
Transcript Identifier
AT1G48050.1
Gene Type
Coding gene
Location
1 : 17723498-17726859 : positive

Family

Gene family
HOM03D005270
(40 genes in 29 species)
specific family
Subfamily
ORTHO03D010534
(25 genes in 23 species)
specific family

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Descriptions

Description
Ku80 family protein
Curated Summary
Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity. Binds double stranded DNA breaks as a heterodimer with Ku70, involved in non-homologous end joining repair. Mutants are defective in T-DNA integration. Over expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.
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Identifiers

Identifier Name
aliasARABIDOPSIS THALIANA KU80 HOMOLOG
aliasKU80
aliasATKU80
uniprotQ9FQ09

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0006303TAS, IEA, UniProtdouble-strand break repair via nonhomologous end joining1 2 3 4 5 6 7 8 9 10
GO:0015074TASUniProtDNA integration1 2 3 4 5 6 7 8 9 10
GO:0000723TAS, IEA, UniProttelomere maintenance1 2 3 4 5 6 7 8 9 10
GO:0006281TASGene OntologyDNA repair1
GO:0009408IEPUniProtresponse to heat1 2 3 4 5 6 7 8 9 10
GO:0006302IMPGene Ontologydouble-strand break repair1
GO:0006342RCAGene Ontologychromatin silencing1
GO:0016572RCAGene Ontologyhistone phosphorylation1
GO:0051567RCAGene Ontologyhistone H3-K9 methylation1
GO:0006310IEAUniProtDNA recombination1 2 3 4 5 6 7 8 9
GO:0000726IEAPLAZA Homologynon-recombinational repairHOM03D005270
GO:0032200IEAPLAZA Homologytelomere organizationHOM03D005270

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0005515IPIGene Ontologyprotein binding1
GO:0003690IDAUniProtdouble-stranded DNA binding1 2 3 4 5 6 7 8 9 10
GO:0003684IEAUniProtdamaged DNA binding1 2 3 4 5 6 7 8 9
GO:0016817IEAInterProhydrolase activity, acting on acid anhydrides
GO:0004003IEAUniProtATP-dependent DNA helicase activity1 2 3 4 5 6 7 8 9
GO:0042162IEAUniProttelomeric DNA binding1 2 3 4 5 6 7 8 9
GO:0003677IEAInterProDNA binding
GO:0005524IEAUniProtATP binding1 2 3 4 5 6 7 8 9

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005634ISM, IEAGene Ontologynucleus1
GO:0043564IEAUniProtKu70:Ku80 complex1 2 3 4 5 6 7 8 9
GO:0005737IEAUniProtcytoplasm1 2 3 4 5 6 7 8 9

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR014893Ku, C-terminal
IPR005160Ku70/Ku80 C-terminal arm
IPR016194SPOC like C-terminal domain
IPR005161Ku70/Ku80, N-terminal alpha/beta
IPR006164Ku70/Ku80 beta-barrel domain
IPR024193Ku80
IPR002035von Willebrand factor, type A

Mapman id Description
30.8signalling.misc
No SignalP domains detected for this gene.