Gene: AT1G24180 (Arabidopsis thaliana)

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Gene Identifier
AT1G24180
Transcript Identifier
AT1G24180.1
Gene Type
Coding gene
Location
1 : 8560777-8563382 : negative

Family

Gene family
HOM03D001278
(121 genes in 31 species)
specific family
Subfamily
ORTHO03D001142
(56 genes in 31 species)
specific family
Duplication type
Block duplicate

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Descriptions

Description
Thiamin diphosphate-binding fold (THDP-binding) superfamily protein
Curated Summary
Arabidopsis thaliana pyruvate dehydrogenase E1a-like subunit. 81% identical to a previously characterized Arabidopsis mitochondrial PDH E1a-subunit, At1g59900. Serine 296 phosphorylation of IAR4 has critical function in root hair formation and root development. Changing Ser296 in IAR4 to Ala resulted in a phenotype intermediate between mutant and wild-type, while substitution to Asp was either lethal or caused an extreme dwarf phenotype.
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Identifiers

Identifier Name
aliasIAA-CONJUGATE-RESISTANT 4
aliasIAR4
uniprotQ8H1Y0

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Biological Process

GO termEvidence(s)ProviderDescriptionSource
GO:0008152ISS, IEAGene Ontologymetabolic process1
GO:0009651IEP, RCA, UniProtresponse to salt stress1 2 3 4 5 6
GO:0006007RCAGene Ontologyglucose catabolic process1
GO:0006098RCAGene Ontologypentose-phosphate shunt1
GO:0009744RCAGene Ontologyresponse to sucrose1
GO:0009749RCAGene Ontologyresponse to glucose1
GO:0009750RCAGene Ontologyresponse to fructose1
GO:0046686RCAGene Ontologyresponse to cadmium ion1
GO:0006096IEAUniProtglycolysis1 2 3 4
GO:0055114IEAInterProoxidation-reduction process

Molecular Function

GO termEvidence(s)ProviderDescriptionSource
GO:0004739IEA, ISSUniProtpyruvate dehydrogenase (acetyl-transferring) activity1 2 3 4 5
GO:0008270IDAUniProtzinc ion binding1 2 3 4 5
GO:0050897IDAUniProtcobalt ion binding1 2 3 4 5
GO:0016624IEAInterProoxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0004738IEAPLAZA Homologypyruvate dehydrogenase activityHOM03D001278

Cellular Component

GO termEvidence(s)ProviderDescriptionSource
GO:0005739IDA, ISM, UniProtmitochondrion1 2 3 4 5 6
GO:0005634IDAUniProtnucleus1 2 3 4 5
GO:0005829IDAUniProtcytosol1 2 3 4 5
GO:0043231IEAInterProintracellular membrane-bounded organelle
GO:0005759IEAUniProtmitochondrial matrix1 2 3 4

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Experimental Evidence
Electronic Evidence
Computational Reviewed Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR017597Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
IPR001017Dehydrogenase, E1 component

Mapman id Description
8.1.1.1TCA / org transformation.TCA.pyruvate DH.E1
No SignalP domains detected for this gene.