PLAZA 3.0 Dicots gene overview : AT1G12550

Gene: AT1G12550 (Arabidopsis thaliana)

Overview

Gene Identifier: AT1G12550
Transcript Identifier: AT1G12550.1
Gene Type: Coding gene
Location: 1 : 4274649-4275831 : positive

Family

Gene family: HOM03D000694
(201 genes in 29 species)
specific family
Subfamily: ORTHO03D013102
(18 genes in 15 species)
specific family
Duplication type: Block duplicate

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Descriptions

Description: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Curated Summary: Encodes a hydroxypyruvate reductase that reduces HP to glycerate and shows even more activity with glyoxylate, a more upstream intermediate of the photorespiratory cycle. It is likely targeted to the chloroplast where it could provide a compensatory bypass for the reduction of HP and glyoxylate within this compartment.

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Identifiers

Identifier	Name
alias	hydroxypyruvate reductase 3
alias	HPR3
uniprot	Q9LE33

Toolbox

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...the colinearity of this gene with other genomes.
...the local gene organization for homologous genes.
...the phylogenetic tree of the homologous gene family.
...the orthologs using the Integrative Orthology Viewer.
...the conserved binding sites (upstream/downstream,intron)

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Biological Process

GO term	Evidence(s)	Provider	Description	Source
GO:0009853	IMP	UniProt	photorespiration	1 2 3
GO:0055114	IDA, IEA	Gene Ontology	oxidation-reduction process	1
GO:0008152	IEA	InterPro	metabolic process
GO:0009854	IEA	UniProt	oxidative photosynthetic carbon pathway	1 2

Molecular Function

GO term	Evidence(s)	Provider	Description	Source
GO:0016491	ISS	Gene Ontology	oxidoreductase activity	1
GO:0016618	IDA	UniProt	hydroxypyruvate reductase activity	1 2 3
GO:0030267	IDA	UniProt	glyoxylate reductase (NADP) activity	1 2 3
GO:0048037	IEA	InterPro	cofactor binding
GO:0051287	IEA	UniProt	NAD binding	1 2
GO:0016616	IEA	InterPro	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016614	IEA	PLAZA Homology	oxidoreductase activity, acting on CH-OH group of donors	HOM03D000694

Cellular Component

GO term	Evidence(s)	Provider	Description	Source
GO:0005737	ISM	Gene Ontology	cytoplasm	1

Color Legend

Experimental Evidence

Electronic Evidence

Computational Reviewed Evidence

InterPro	Description
IPR006140	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
IPR006139	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
IPR016040	NAD(P)-binding domain

Mapman id	Description
1.2.6	PS.photorespiration.hydroxypyruvate reductase

No SignalP domains detected for this gene.