Gene: FBgn0002121 (Drosophila melanogaster)

Overview top

Gene Identifier
FBgn0002121
Transcript Identifier
FBtr0078171
Gene Type
Coding gene
Location
2L : 11215-17136 : negative

Family Information

Homologous gene family
HOM03P007354
(12 genes in 7 species)
specific family
Orthologous gene family
ORTHO03P066017
(2 genes in 2 species)
specific family

Descriptions

gene_descr
lethal (2) giant larvae

Identifiers

Type Value
pidFBpp0077829
UniprotP08111
UniprotM9NCX1

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000132
IMP
Genome Projectestablishment of mitotic spindle orientation
GO:0001738
TAS
Genome Projectmorphogenesis of a polarized epithelium
GO:0002009
TAS
Genome Projectmorphogenesis of an epithelium
GO:0006469
IDA
Genome Projectnegative regulation of protein kinase activity
GO:0006887
IEA
Genome Projectexocytosis
GO:0007049
IEA
Genome Projectcell cycle
GO:0007179
IMP, IGI
Genome Projecttransforming growth factor beta receptor signaling pathway
GO:0007269
NAS
Genome Projectneurotransmitter secretion
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007293
IMP
Genome Projectgermarium-derived egg chamber formation
GO:0007314
IMP
Genome Projectoocyte anterior/posterior axis specification
GO:0007391
TAS
Genome Projectdorsal closure
GO:0007399
IMP
Genome Projectnervous system development
GO:0007406
IMP
Genome Projectnegative regulation of neuroblast proliferation
GO:0007423
IMP
Genome Projectsensory organ development
GO:0008104
TAS
Genome Projectprotein localization
GO:0008105
IMP
TAS
Genome Projectasymmetric protein localization
GO:0008283
TAS
Genome Projectcell proliferation
GO:0008285
TAS
Genome Projectnegative regulation of cell proliferation
GO:0008360
NAS
Genome Projectregulation of cell shape
GO:0016082
NAS
Genome Projectsynaptic vesicle priming
GO:0016325
IMP
Genome Projectoocyte microtubule cytoskeleton organization
GO:0016332
TAS
Genome Projectestablishment or maintenance of polarity of embryonic epithelium
GO:0016333
IMP
Genome Projectmorphogenesis of follicular epithelium
GO:0016334
IGI
Genome Projectestablishment or maintenance of polarity of follicular epithelium
GO:0016335
TAS
Genome Projectmorphogenesis of larval imaginal disc epithelium
GO:0016336
TAS
Genome Projectestablishment or maintenance of polarity of larval imaginal disc epithelium
GO:0019991
TAS
Genome Projectseptate junction assembly
GO:0030036
IMP
Genome Projectactin cytoskeleton organization
GO:0035070
IMP
Genome Projectsalivary gland histolysis
GO:0035072
IMP
Genome Projectecdysone-mediated induction of salivary gland cell autophagic cell death
GO:0035212
IMP
Genome Projectcell competition in a multicellular organism
GO:0035293
IMP
Genome Projectchitin-based larval cuticle pattern formation
GO:0045167
IPI, IMP
TAS
Genome Projectasymmetric protein localization involved in cell fate determination
GO:0045175
IMP, IGI
NAS
Genome Projectbasal protein localization
GO:0045176
IMP
Genome Projectapical protein localization
GO:0045184
IMP
Genome Projectestablishment of protein localization
GO:0045196
IGI
TAS
Genome Projectestablishment or maintenance of neuroblast polarity
GO:0045197
TAS, NAS
Genome Projectestablishment or maintenance of epithelial cell apical/basal polarity
GO:0045200
TAS
Genome Projectestablishment of neuroblast polarity
GO:0045746
IGI
Genome Projectnegative regulation of Notch signaling pathway
GO:0048730
IMP
Genome Projectepidermis morphogenesis
GO:0051668
IMP
Genome Projectlocalization within membrane
GO:0051726
NAS
Genome Projectregulation of cell cycle
GO:0055059
IGI
Genome Projectasymmetric neuroblast division
GO:0060429
IMP
Genome Projectepithelium development
GO:0072697
IMP
Genome Projectprotein localization to cell cortex
GO:0090163
IMP
Genome Projectestablishment of epithelial cell planar polarity
GO:0098725
IMP
Genome Projectsymmetric cell division
GO:1904030
IDA
Genome Projectnegative regulation of cyclin-dependent protein kinase activity

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000149
IPI
Genome ProjectSNARE binding
GO:0004860
IDA
Genome Projectprotein kinase inhibitor activity
GO:0017022
IGI
Genome Projectmyosin binding
GO:0045159
IGI
TAS
Genome Projectmyosin II binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005578
IDA
IEA
Genome Projectproteinaceous extracellular matrix
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005829
TAS
Genome Projectcytosol
GO:0005856
NAS
Genome Projectcytoskeleton
GO:0005886
IDA
TAS, IEA
Genome Projectplasma membrane
GO:0005918
TAS, NAS
Genome Projectseptate junction
GO:0005920
IDA
Genome Projectsmooth septate junction
GO:0005938
IDA
TAS
Genome Projectcell cortex
GO:0008021
NAS
Genome Projectsynaptic vesicle
GO:0016020
IEA
Genome Projectmembrane
GO:0016323
TAS
Genome Projectbasolateral plasma membrane
GO:0016327
IDA
Genome Projectapicolateral plasma membrane
GO:0030863
IDA
Genome Projectcortical cytoskeleton

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000664Lethal(2) giant larvae protein
IPR001680WD40 repeat
IPR013577Lethal giant larvae homologue 2
IPR013905Lethal giant larvae (Lgl)-like, C-terminal domain
IPR015943WD40/YVTN repeat-like-containing domain
IPR017986WD40-repeat-containing domain

No MapMan annotations defined for this gene.