Gene: ENSMUSG00000097297 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000097297
Transcript Identifier
ENSMUST00000181320
Gene Type
Coding gene
Location
CHR_MG4151_PATCH : 221147-248169 : negative

Family Information

Homologous gene family
HOM03P001064
(59 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P000963
(41 genes in 2 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
NACHT, LRR and PYD domains-containing protein 12

Identifiers

Type Value
UniprotE9Q5R7
UniprotNlrp12-202
MGI

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008588
ISO
IEA
Genome Projectrelease of cytoplasmic sequestered NF-kappaB
GO:0009968
ISO
IEA
Genome Projectnegative regulation of signal transduction
GO:0031953
ISO
IEA
Genome Projectnegative regulation of protein autophosphorylation
GO:0032088
ISO
IEA
Genome Projectnegative regulation of NF-kappaB transcription factor activity
GO:0036336
IMP
Genome Projectdendritic cell migration
GO:0043122
ISO
IEA
Genome Projectregulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124
ISO
IEA
Genome Projectnegative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043281
ISO
IEA
Genome Projectregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045345
ISO
IEA
Genome Projectpositive regulation of MHC class I biosynthetic process
GO:0045409
ISO
IEA
Genome Projectnegative regulation of interleukin-6 biosynthetic process
GO:0045751
ISO
IEA
Genome Projectnegative regulation of Toll signaling pathway
GO:0050710
ISO
IEA
Genome Projectnegative regulation of cytokine secretion
GO:0050711
ISO
IEA
Genome Projectnegative regulation of interleukin-1 secretion
GO:0050728
ISO
IEA
Genome Projectnegative regulation of inflammatory response
GO:0070373
IMP
Genome Projectnegative regulation of ERK1 and ERK2 cascade
GO:0071345
IMP
Genome Projectcellular response to cytokine stimulus
GO:1901223
IMP
Genome Projectnegative regulation of NIK/NF-kappaB signaling

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005515
IEA
InterProprotein binding
GO:0005524
IEA
Genome ProjectATP binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005634
ISO
Genome Projectnucleus

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR027417P-loop containing nucleoside triphosphate hydrolase
IPR011029Death-like domain
IPR004020DAPIN domain
IPR029495NACHT-associated domain
IPR001611Leucine-rich repeat
IPR007111NACHT nucleoside triphosphatase
IPR003590Leucine-rich repeat, ribonuclease inhibitor subtype

No MapMan annotations defined for this gene.