Gene: ENSMUSG00000074934 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000074934
Transcript Identifier
ENSMUST00000099575
Gene Type
Coding gene
Location
2 : 113749600-113750154 : negative

Family Information

Homologous gene family
HOM03P011984
(7 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P024978
(4 genes in 2 species)
specific family

Descriptions

gene_descr
gremlin 1

Identifiers

Type Value
UniprotO70326
UniprotQ3TNY7
MGI1344337

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000902
ISO
IEA
Genome Projectcell morphogenesis
GO:0001525
IDA
Genome Projectangiogenesis
GO:0001658
IGI
Genome Projectbranching involved in ureteric bud morphogenesis
GO:0002042
IDA
Genome Projectcell migration involved in sprouting angiogenesis
GO:0002092
IDA
Genome Projectpositive regulation of receptor internalization
GO:0002689
IEA
Genome Projectnegative regulation of leukocyte chemotaxis
GO:0003257
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003337
IDA
Genome Projectmesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007165
IDA
Genome Projectsignal transduction
GO:0007171
IDA
Genome Projectactivation of transmembrane receptor protein tyrosine kinase activity
GO:0007267
IMP
Genome Projectcell-cell signaling
GO:0008284
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0009887
IMP
Genome Projectorgan morphogenesis
GO:0009954
IMP
Genome Projectproximal/distal pattern formation
GO:0010717
ISO
IEA
Genome Projectregulation of epithelial to mesenchymal transition
GO:0030199
ISO
IEA
Genome Projectcollagen fibril organization
GO:0030308
IEA
Genome Projectnegative regulation of cell growth
GO:0030326
IMP
Genome Projectembryonic limb morphogenesis
GO:0030502
ISO
IEA
Genome Projectnegative regulation of bone mineralization
GO:0030514
IMP
ISO
IEA
Genome Projectnegative regulation of BMP signaling pathway
GO:0032331
ISO
IEA
Genome Projectnegative regulation of chondrocyte differentiation
GO:0033689
ISO
IEA
Genome Projectnegative regulation of osteoblast proliferation
GO:0042346
IDA
Genome Projectpositive regulation of NF-kappaB import into nucleus
GO:0043066
ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043542
IDA
Genome Projectendothelial cell migration
GO:0045766
IMP
IEA
Genome Projectpositive regulation of angiogenesis
GO:0045892
IMP
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045893
IDA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0045944
IDA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046851
ISO
IEA
Genome Projectnegative regulation of bone remodeling
GO:0048263
ISO
IEA
Genome Projectdetermination of dorsal identity
GO:0051092
IDA
Genome Projectpositive regulation of NF-kappaB transcription factor activity
GO:0051893
IDA
Genome Projectregulation of focal adhesion assembly
GO:0051973
ISO
IEA
Genome Projectpositive regulation of telomerase activity
GO:0060173
ISO
IEA
Genome Projectlimb development
GO:0060394
ISO
IEA
Genome Projectnegative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060676
IDA
Genome Projectureteric bud formation
GO:0061098
IDA
Genome Projectpositive regulation of protein tyrosine kinase activity
GO:0090027
IEA
Genome Projectnegative regulation of monocyte chemotaxis
GO:0090090
ISO
IEA
Genome Projectnegative regulation of canonical Wnt signaling pathway
GO:0090190
IDA
Genome Projectpositive regulation of branching involved in ureteric bud morphogenesis
GO:0090191
IDA
Genome Projectnegative regulation of branching involved in ureteric bud morphogenesis
GO:0090291
ISO
IEA
Genome Projectnegative regulation of osteoclast proliferation
GO:1900086
IDA
Genome Projectpositive regulation of peptidyl-tyrosine autophosphorylation
GO:1900155
ISO
IEA
Genome Projectnegative regulation of bone trabecula formation
GO:1900158
ISO
IEA
Genome Projectnegative regulation of bone mineralization involved in bone maturation
GO:2000273
IDA
Genome Projectpositive regulation of receptor activity
GO:2000727
IDA
Genome Projectpositive regulation of cardiac muscle cell differentiation
GO:0032872
IDA
Genome Projectregulation of stress-activated MAPK cascade
GO:0072331
IGI
Genome Projectsignal transduction by p53 class mediator

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005125
IEA
Genome Projectcytokine activity
GO:0030297
IDA
Genome Projecttransmembrane receptor protein tyrosine kinase activator activity
GO:0043184
IPI
Genome Projectvascular endothelial growth factor receptor 2 binding
GO:0043395
TAS
Genome Projectheparan sulfate proteoglycan binding
GO:0048018
IPI
Genome Projectreceptor agonist activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IEA
Genome Projectextracellular region
GO:0005615
IDA
IEA
Genome Projectextracellular space
GO:0009986
IDA
IEA
Genome Projectcell surface

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR004133DAN
IPR006207Cystine knot, C-terminal
IPR017159Gremlin-1/2

No MapMan annotations defined for this gene.