Gene: ENSMUSG00000066877 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000066877
Transcript Identifier
ENSMUST00000086421
Gene Type
Coding gene
Location
1 : 43533568-43569342 : positive

Family Information

Homologous gene family
HOM03P006490
(13 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P014998
(6 genes in 4 species)
specific family

Descriptions

gene_descr
non-catalytic region of tyrosine kinase adaptor protein 2

Identifiers

Type Value
UniprotO55033
MGI1306821

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001771
ISO
IEA
Genome Projectimmunological synapse formation
GO:0006417
IEA
Genome Projectregulation of translation
GO:0007015
IMP
Genome Projectactin filament organization
GO:0016477
IMP
Genome Projectcell migration
GO:0030032
IMP
Genome Projectlamellipodium assembly
GO:0030838
ISO
IEA
Genome Projectpositive regulation of actin filament polymerization
GO:0033137
ISO
IEA
Genome Projectnegative regulation of peptidyl-serine phosphorylation
GO:0036493
IGI
Genome Projectpositive regulation of translation in response to endoplasmic reticulum stress
GO:0042102
ISO
IEA
Genome Projectpositive regulation of T cell proliferation
GO:0045944
ISO
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0048013
IDA
Genome Projectephrin receptor signaling pathway
GO:0060996
ISO
IEA
Genome Projectdendritic spine development
GO:1902237
IGI
Genome Projectpositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903898
IGI
Genome Projectnegative regulation of PERK-mediated unfolded protein response
GO:1903912
IGI
ISO
IEA
Genome Projectnegative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:1990441
IGI
Genome Projectnegative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0032403
IPI
Genome Projectprotein complex binding
GO:0097110
IPI
Genome Projectscaffold protein binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005783
ISO
IEA
Genome Projectendoplasmic reticulum
GO:0012506
IDA
Genome Projectvesicle membrane
GO:0045202
ISO
IEA
Genome Projectsynapse
GO:0097481
ISO
IEA
Genome Projectneuronal postsynaptic density

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000980SH2 domain
IPR001452SH3 domain
IPR017304Cytoplasmic protein NCK

No MapMan annotations defined for this gene.