Gene: ENSMUSG00000066551 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000066551
Transcript Identifier
ENSMUST00000093196
Gene Type
Coding gene
Location
5 : 149048737-149050737 : negative

Family Information

Homologous gene family
HOM03P000209
(166 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P020847
(5 genes in 5 species)
specific family

Descriptions

gene_descr
high mobility group box 1

Identifiers

Type Value
UniprotP63158
UniprotQ58EV5
MGI96113

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000122
IEA
Genome Projectnegative regulation of transcription from RNA polymerase II promoter
GO:0001773
IMP
Genome Projectmyeloid dendritic cell activation
GO:0001935
IDA
Genome Projectendothelial cell proliferation
GO:0002270
IMP
Genome Projectplasmacytoid dendritic cell activation
GO:0002281
IMP
Genome Projectmacrophage activation involved in immune response
GO:0002437
IEA
Genome Projectinflammatory response to antigenic stimulus
GO:0006288
IEA
Genome Projectbase-excision repair, DNA ligation
GO:0006357
IEA
Genome Projectregulation of transcription from RNA polymerase II promoter
GO:0006954
TAS, IEA
Genome Projectinflammatory response
GO:0017055
IEA
Genome Projectnegative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0032392
ISS
Genome ProjectDNA geometric change
GO:0032727
IMP
Genome Projectpositive regulation of interferon-alpha production
GO:0032728
IMP
Genome Projectpositive regulation of interferon-beta production
GO:0032755
IMP
Genome Projectpositive regulation of interleukin-6 production
GO:0032760
IMP
Genome Projectpositive regulation of tumor necrosis factor production
GO:0033151
IEA
Genome ProjectV(D)J recombination
GO:0035767
IDA
Genome Projectendothelial cell chemotaxis
GO:0043065
IEA
Genome Projectpositive regulation of apoptotic process
GO:0043280
IEA
Genome Projectpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388
IEA
Genome Projectpositive regulation of DNA binding
GO:0043537
IEA
Genome Projectnegative regulation of blood vessel endothelial cell migration
GO:0045089
IMP
Genome Projectpositive regulation of innate immune response
GO:0045944
IEA
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0050718
IMP
Genome Projectpositive regulation of interleukin-1 beta secretion
GO:0070374
IDA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0090303
IDA
Genome Projectpositive regulation of wound healing
GO:1903672
IDA
Genome Projectpositive regulation of sprouting angiogenesis
GO:2000426
IDA
Genome Projectnegative regulation of apoptotic cell clearance

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000400
ISS
Genome Projectfour-way junction DNA binding
GO:0000405
ISS
Genome Projectbubble DNA binding
GO:0001786
TAS
Genome Projectphosphatidylserine binding
GO:0003677
IEA
Genome ProjectDNA binding
GO:0003690
IDA
Genome Projectdouble-stranded DNA binding
GO:0003700
IEA
Genome Projecttranscription factor activity, sequence-specific DNA binding
GO:0003725
IDA
Genome Projectdouble-stranded RNA binding
GO:0003727
IDA
Genome Projectsingle-stranded RNA binding
GO:0005125
IEA
Genome Projectcytokine activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0008134
IEA
Genome Projecttranscription factor binding
GO:0008201
IEA
Genome Projectheparin binding
GO:0008301
ISS
Genome ProjectDNA binding, bending
GO:0044822
IEA
Genome Projectpoly(A) RNA binding
GO:0070491
IEA
Genome Projectrepressing transcription factor binding
GO:0097100
ISS
Genome Projectsupercoiled DNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000793
IEA
Genome Projectcondensed chromosome
GO:0005576
TAS
Genome Projectextracellular region
GO:0005615
IEA
Genome Projectextracellular space
GO:0005634
IEA
Genome Projectnucleus
GO:0005694
IEA
Genome Projectchromosome
GO:0005737
IEA
Genome Projectcytoplasm
GO:0005769
IDA
Genome Projectearly endosome
GO:0009986
IEA
Genome Projectcell surface
GO:0017053
IEA
Genome Projecttranscriptional repressor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR009071High mobility group box domain
IPR017967HMG box A DNA-binding domain, conserved site
IPR031076High mobility group protein HMGB1

No MapMan annotations defined for this gene.