Gene: ENSMUSG00000063358 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000063358
Transcript Identifier
ENSMUST00000115731
Gene Type
Coding gene
Location
16 : 16983627-17038430 : positive

Family Information

Homologous gene family
HOM03P000009
(1563 genes in 39 species)
specific family
Orthologous gene family
ORTHO03P000210
(62 genes in 33 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
mitogen-activated protein kinase 1

Identifiers

Type Value
UniprotP63085
MGI1346858

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IDA
IEA
Genome ProjectMAPK cascade
GO:0000189
IEA
Genome ProjectMAPK import into nucleus
GO:0006351
NAS
Genome Projecttranscription, DNA-templated
GO:0006468
IDA, IMP
ISO
IEA
Genome Projectprotein phosphorylation
GO:0006915
IEA
Genome Projectapoptotic process
GO:0006974
IDA
Genome Projectcellular response to DNA damage stimulus
GO:0007049
IEA
Genome Projectcell cycle
GO:0007165
IEA
Genome Projectsignal transduction
GO:0008284
IEA
Genome Projectpositive regulation of cell proliferation
GO:0009636
IEA
Genome Projectresponse to toxic substance
GO:0009887
IDA
Genome Projectorgan morphogenesis
GO:0010800
ISO
IEA
Genome Projectpositive regulation of peptidyl-threonine phosphorylation
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018105
IDA, IMP
ISO
IEA
Genome Projectpeptidyl-serine phosphorylation
GO:0018107
IDA
Genome Projectpeptidyl-threonine phosphorylation
GO:0019233
IEA
Genome Projectsensory perception of pain
GO:0019858
IDA
Genome Projectcytosine metabolic process
GO:0030335
IEA
Genome Projectpositive regulation of cell migration
GO:0031647
ISS
Genome Projectregulation of protein stability
GO:0031663
IDA
Genome Projectlipopolysaccharide-mediated signaling pathway
GO:0032496
IDA
Genome Projectresponse to lipopolysaccharide
GO:0032872
TAS
Genome Projectregulation of stress-activated MAPK cascade
GO:0033598
IDA
Genome Projectmammary gland epithelial cell proliferation
GO:0035556
IEA
Genome Projectintracellular signal transduction
GO:0038127
ISO
IEA
Genome ProjectERBB signaling pathway
GO:0043330
IDA
Genome Projectresponse to exogenous dsRNA
GO:0043627
IEA
Genome Projectresponse to estrogen
GO:0045596
IGI
Genome Projectnegative regulation of cell differentiation
GO:0045727
IEA
Genome Projectpositive regulation of translation
GO:0045893
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0050852
IDA
Genome ProjectT cell receptor signaling pathway
GO:0050853
IDA
Genome ProjectB cell receptor signaling pathway
GO:0051090
NAS
Genome Projectregulation of sequence-specific DNA binding transcription factor activity
GO:0051493
TAS
Genome Projectregulation of cytoskeleton organization
GO:0060291
IGI
Genome Projectlong-term synaptic potentiation
GO:0060425
IGI
Genome Projectlung morphogenesis
GO:0060440
IGI
Genome Projecttrachea formation
GO:0060716
IMP
Genome Projectlabyrinthine layer blood vessel development
GO:0070371
IGI
ISO
IEA
Genome ProjectERK1 and ERK2 cascade
GO:0070849
ISS, ISO
IEA
Genome Projectresponse to epidermal growth factor
GO:0071310
IEA
Genome Projectcellular response to organic substance
GO:0072584
TAS
Genome Projectcaveolin-mediated endocytosis
GO:0090170
TAS
Genome Projectregulation of Golgi inheritance
GO:0097011
IDA
Genome Projectcellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:2000641
TAS
Genome Projectregulation of early endosome to late endosome transport

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0001784
IMP
Genome Projectphosphotyrosine binding
GO:0004672
IDA
IEA
Genome Projectprotein kinase activity
GO:0004674
IDA
ISO
IEA
Genome Projectprotein serine/threonine kinase activity
GO:0004707
IDA, IMP
IEA
Genome ProjectMAP kinase activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0008134
IEA
Genome Projecttranscription factor binding
GO:0008353
IDA
Genome ProjectRNA polymerase II carboxy-terminal domain kinase activity
GO:0016301
IDA
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0019901
IEA
Genome Projectprotein kinase binding
GO:0019902
ISO
IEA
Genome Projectphosphatase binding
GO:0031435
IEA
Genome Projectmitogen-activated protein kinase kinase kinase binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IDA
ISO
TAS, IEA
Genome Projectnucleus
GO:0005654
ISO
TAS, IEA
Genome Projectnucleoplasm
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0005739
IDA
TAS
Genome Projectmitochondrion
GO:0005769
TAS
Genome Projectearly endosome
GO:0005770
TAS
Genome Projectlate endosome
GO:0005794
TAS
Genome ProjectGolgi apparatus
GO:0005815
IEA
Genome Projectmicrotubule organizing center
GO:0005819
IEA
Genome Projectspindle
GO:0005829
IDA
TAS
Genome Projectcytosol
GO:0005856
TAS, IEA
Genome Projectcytoskeleton
GO:0005901
TAS
Genome Projectcaveola
GO:0005925
TAS
Genome Projectfocal adhesion
GO:0015630
ISO
IEA
Genome Projectmicrotubule cytoskeleton
GO:0030424
IEA
Genome Projectaxon
GO:0031143
IDA
Genome Projectpseudopodium
GO:0032839
IEA
Genome Projectdendrite cytoplasm
GO:0043204
IEA
Genome Projectperikaryon
GO:0043234
IEA
Genome Projectprotein complex
GO:0070062
ISO
IEA
Genome Projectextracellular exosome
GO:0072686
ISS
Genome Projectmitotic spindle

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000719Protein kinase domain
IPR002290Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003527Mitogen-activated protein (MAP) kinase, conserved site
IPR008271Serine/threonine-protein kinase, active site
IPR008349Mitogen-activated protein (MAP) kinase, ERK1/2
IPR011009Protein kinase-like domain
IPR017441Protein kinase, ATP binding site

No MapMan annotations defined for this gene.