Gene: ENSMUSG00000062991 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000062991
Transcript Identifier
ENSMUST00000073884
Gene Type
Coding gene
Location
8 : 31818028-31918203 : negative

Family Information

Homologous gene family
HOM03P013894
(6 genes in 3 species)
specific family
Orthologous gene family
ORTHO03P064436
(2 genes in 2 species)
specific family

Descriptions

gene_descr
neuregulin 1

Identifiers

Type Value
UniprotQ6DR99
MGI96083

Toolbox

Explore

Create

View

Browse

 

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000165
IDA
Genome ProjectMAPK cascade
GO:0000902
IDA
Genome Projectcell morphogenesis
GO:0001964
IMP
Genome Projectstartle response
GO:0003161
IDA
Genome Projectcardiac conduction system development
GO:0003222
IEA
Genome Projectventricular trabecula myocardium morphogenesis
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171
IBA
Genome Projectactivation of transmembrane receptor protein tyrosine kinase activity
GO:0007399
IMP
Genome Projectnervous system development
GO:0007416
IMP
Genome Projectsynapse assembly
GO:0007420
IMP
Genome Projectbrain development
GO:0007422
IMP
Genome Projectperipheral nervous system development
GO:0007507
IMP
Genome Projectheart development
GO:0007517
IMP
Genome Projectmuscle organ development
GO:0007626
IMP
Genome Projectlocomotory behavior
GO:0008283
IEA
Genome Projectcell proliferation
GO:0008366
IMP
Genome Projectaxon ensheathment
GO:0009790
IEA
Genome Projectembryo development
GO:0010001
IMP
Genome Projectglial cell differentiation
GO:0010667
IEA
Genome Projectnegative regulation of cardiac muscle cell apoptotic process
GO:0014068
IGI
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477
IGI
Genome Projectcell migration
GO:0021781
IDA
Genome Projectglial cell fate commitment
GO:0021842
IMP
Genome Projectchemorepulsion involved in interneuron migration from the subpallium to the cortex
GO:0022008
IMP, IGI
Genome Projectneurogenesis
GO:0030307
IEA
Genome Projectpositive regulation of cell growth
GO:0031643
IMP
Genome Projectpositive regulation of myelination
GO:0038127
IEA
Genome ProjectERBB signaling pathway
GO:0042060
IEA
Genome Projectwound healing
GO:0042177
IDA
Genome Projectnegative regulation of protein catabolic process
GO:0043497
IEA
Genome Projectregulation of protein heterodimerization activity
GO:0043624
ISO
IEA
Genome Projectcellular protein complex disassembly
GO:0045213
IMP
Genome Projectneurotransmitter receptor metabolic process
GO:0045595
IMP
Genome Projectregulation of cell differentiation
GO:0045773
IMP
Genome Projectpositive regulation of axon extension
GO:0045785
IEA
Genome Projectpositive regulation of cell adhesion
GO:0045860
IDA
Genome Projectpositive regulation of protein kinase activity
GO:0045892
ISO
IEA
Genome Projectnegative regulation of transcription, DNA-templated
GO:0045944
IMP
Genome Projectpositive regulation of transcription from RNA polymerase II promoter
GO:0046579
IDA
Genome Projectpositive regulation of Ras protein signal transduction
GO:0048663
IMP
Genome Projectneuron fate commitment
GO:0048709
IMP
Genome Projectoligodendrocyte differentiation
GO:0050731
IDA
Genome Projectpositive regulation of peptidyl-tyrosine phosphorylation
GO:0051048
IEA
Genome Projectnegative regulation of secretion
GO:0051897
IDA
Genome Projectpositive regulation of protein kinase B signaling
GO:0055012
IEA
Genome Projectventricular cardiac muscle cell differentiation
GO:0060045
IEA
Genome Projectpositive regulation of cardiac muscle cell proliferation
GO:0060379
IEA
Genome Projectcardiac muscle cell myoblast differentiation
GO:0060956
IEA
Genome Projectendocardial cell differentiation
GO:0060999
IMP
Genome Projectpositive regulation of dendritic spine development
GO:0061098
IEA
Genome Projectpositive regulation of protein tyrosine kinase activity
GO:0070886
IGI
Genome Projectpositive regulation of calcineurin-NFAT signaling cascade
GO:1903955
IEA
Genome Projectpositive regulation of protein targeting to mitochondrion
GO:2000010
IGI
Genome Projectpositive regulation of protein localization to cell surface
GO:2000727
IMP
Genome Projectpositive regulation of cardiac muscle cell differentiation
GO:2001223
IDA
Genome Projectnegative regulation of neuron migration
GO:2001240
IEA
Genome Projectnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0003712
ISO
IEA
Genome Projecttranscription cofactor activity
GO:0005102
IEA
Genome Projectreceptor binding
GO:0005176
IDA, IGI
Genome ProjectErbB-2 class receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008083
IEA
Genome Projectgrowth factor activity
GO:0030296
IBA
IEA
Genome Projectprotein tyrosine kinase activator activity
GO:0043125
IEA
Genome ProjectErbB-3 class receptor binding
GO:0045499
IDA
Genome Projectchemorepellent activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005576
IDA
Genome Projectextracellular region
GO:0005615
IBA
IEA
Genome Projectextracellular space
GO:0005634
IDA
Genome Projectnucleus
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005886
IDA
Genome Projectplasma membrane
GO:0005887
IDA
Genome Projectintegral component of plasma membrane
GO:0009897
IDA
Genome Projectexternal side of plasma membrane
GO:0016324
IEA
Genome Projectapical plasma membrane
GO:0030424
IDA
Genome Projectaxon
GO:0030425
IDA
Genome Projectdendrite
GO:0030673
IDA
Genome Projectaxolemma
GO:0031594
IDA
Genome Projectneuromuscular junction
GO:0044297
IDA
Genome Projectcell body
GO:0045202
IDA
Genome Projectsynapse

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000742EGF-like domain
IPR002154Neuregulin, C-terminal
IPR013032EGF-like, conserved site
IPR018250Neuregulin-1

No MapMan annotations defined for this gene.