Gene: ENSMUSG00000062232 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000062232
Transcript Identifier
ENSMUST00000195708
Gene Type
Coding gene
Location
3 : 79064536-79286493 : negative

Family Information

Homologous gene family
HOM03P001034
(60 genes in 9 species)
specific family
Orthologous gene family
ORTHO03P015030
(6 genes in 4 species)
specific family

Descriptions

gene_descr
Rap guanine nucleotide exchange factor (GEF) 2

Identifiers

Type Value
UniprotA0A0A6YWG7
MGI2659071

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0007165
IEA
Genome Projectsignal transduction
GO:0007186
ISO
Genome ProjectG-protein coupled receptor signaling pathway
GO:0007218
ISO
Genome Projectneuropeptide signaling pathway
GO:0007264
IEA
Genome Projectsmall GTPase mediated signal transduction
GO:0008285
ISO
Genome Projectnegative regulation of cell proliferation
GO:0019933
ISO
Genome ProjectcAMP-mediated signaling
GO:0030033
ISO
Genome Projectmicrovillus assembly
GO:0031175
ISO
Genome Projectneuron projection development
GO:0032486
ISO
Genome ProjectRap protein signal transduction
GO:0042127
IEA
Genome Projectregulation of cell proliferation
GO:0043547
ISO
IEA
Genome Projectpositive regulation of GTPase activity
GO:0043950
ISO
Genome Projectpositive regulation of cAMP-mediated signaling
GO:0045860
ISO
Genome Projectpositive regulation of protein kinase activity
GO:0050774
ISO
Genome Projectnegative regulation of dendrite morphogenesis
GO:0061028
ISO
Genome Projectestablishment of endothelial barrier
GO:0070374
ISO
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:0071320
ISO
Genome Projectcellular response to cAMP
GO:0071321
ISO
Genome Projectcellular response to cGMP
GO:0071880
ISO
Genome Projectadenylate cyclase-activating adrenergic receptor signaling pathway
GO:0072659
ISO
Genome Projectprotein localization to plasma membrane
GO:0090557
ISO
Genome Projectestablishment of endothelial intestinal barrier
GO:1901888
ISO
Genome Projectregulation of cell junction assembly
GO:2000481
ISO
Genome Projectpositive regulation of cAMP-dependent protein kinase activity
GO:2000670
ISO
Genome Projectpositive regulation of dendritic cell apoptotic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005085
IEA
Genome Projectguanyl-nucleotide exchange factor activity
GO:0005088
ISO
Genome ProjectRas guanyl-nucleotide exchange factor activity
GO:0005096
ISO
IEA
Genome ProjectGTPase activator activity
GO:0017034
ISO
IEA
Genome ProjectRap guanyl-nucleotide exchange factor activity
GO:0030165
ISO
Genome ProjectPDZ domain binding
GO:0031697
ISO
Genome Projectbeta-1 adrenergic receptor binding
GO:0050699
ISO
Genome ProjectWW domain binding
GO:0070300
ISO
Genome Projectphosphatidic acid binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
ISO
Genome Projectcytoplasm
GO:0005770
ISO
Genome Projectlate endosome
GO:0005829
ISO
Genome Projectcytosol
GO:0005923
ISO
Genome Projectbicellular tight junction
GO:0016020
ISO
Genome Projectmembrane
GO:0016324
ISO
Genome Projectapical plasma membrane
GO:0030139
ISO
Genome Projectendocytic vesicle
GO:0048471
ISO
Genome Projectperinuclear region of cytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR000159Ras-associating (RA) domain
IPR000595Cyclic nucleotide-binding domain
IPR000651Ras-like guanine nucleotide exchange factor, N-terminal
IPR001478PDZ domain
IPR001895Ras guanine-nucleotide exchange factors catalytic domain
IPR014710RmlC-like jelly roll fold
IPR018490Cyclic nucleotide-binding-like
IPR023578Ras guanine nucleotide exchange factor domain
IPR029071Ubiquitin-related domain
IPR030739Rap guanine nucleotide exchange factor 2

No MapMan annotations defined for this gene.