Gene: ENSMUSG00000062209 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000062209
Transcript Identifier
ENSMUST00000119142
Gene Type
Coding gene
Location
1 : 68040041-69107756 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P009161
(9 genes in 4 species)
specific family
Duplication type
Block duplicate

Descriptions

gene_descr
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)

Identifiers

Type Value
UniprotQ61527
MGI104771

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001755
IMP
Genome Projectneural crest cell migration
GO:0006351
IEA
Genome Projecttranscription, DNA-templated
GO:0006355
IEA
Genome Projectregulation of transcription, DNA-templated
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0006915
IEA
Genome Projectapoptotic process
GO:0007165
ISO
IEA
Genome Projectsignal transduction
GO:0007169
ISS, ISO
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007399
IMP
Genome Projectnervous system development
GO:0007507
IMP
Genome Projectheart development
GO:0007595
IMP
ISO
IEA
Genome Projectlactation
GO:0008284
ISS, ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0008285
ISS, ISO
IEA
Genome Projectnegative regulation of cell proliferation
GO:0009880
IMP
Genome Projectembryonic pattern specification
GO:0014068
IGI
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016310
IEA
Genome Projectphosphorylation
GO:0016477
ISS, ISO
IEA
Genome Projectcell migration
GO:0018108
ISS, ISO
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0021551
IMP
Genome Projectcentral nervous system morphogenesis
GO:0021889
IMP
Genome Projectolfactory bulb interneuron differentiation
GO:0023014
IEA
Genome Projectsignal transduction by protein phosphorylation
GO:0030334
IMP
Genome Projectregulation of cell migration
GO:0042523
IMP
ISO
IEA
Genome Projectpositive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066
ISS, ISO
IEA
Genome Projectnegative regulation of apoptotic process
GO:0043552
ISS
IEA
Genome Projectpositive regulation of phosphatidylinositol 3-kinase activity
GO:0043653
ISS, ISO
IEA
Genome Projectmitochondrial fragmentation involved in apoptotic process
GO:0045165
IDA
Genome Projectcell fate commitment
GO:0045893
IMP
ISO
IEA
Genome Projectpositive regulation of transcription, DNA-templated
GO:0046777
ISS, ISO
IEA
Genome Projectprotein autophosphorylation
GO:0060045
IMP
Genome Projectpositive regulation of cardiac muscle cell proliferation
GO:0060644
IMP
Genome Projectmammary gland epithelial cell differentiation
GO:0060749
IMP
Genome Projectmammary gland alveolus development
GO:0061026
IMP
Genome Projectcardiac muscle tissue regeneration
GO:0070374
ISS, ISO
IEA
Genome Projectpositive regulation of ERK1 and ERK2 cascade
GO:2000010
IGI
Genome Projectpositive regulation of protein localization to cell surface
GO:2000366
IMP
ISO
IEA
Genome Projectpositive regulation of STAT protein import into nucleus
GO:2001223
IMP
Genome Projectnegative regulation of neuron migration

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
ISO
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
ISS, ISO
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0004716
IEA
Genome Projectreceptor signaling protein tyrosine kinase activity
GO:0005154
ISO
IEA
Genome Projectepidermal growth factor receptor binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0042803
ISO
IEA
Genome Projectprotein homodimerization activity
GO:0044212
ISO
IEA
Genome Projecttranscription regulatory region DNA binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
ISO
IEA
Genome Projectnucleus
GO:0005739
ISO
IEA
Genome Projectmitochondrion
GO:0005886
IEA
Genome Projectplasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0016323
ISO
IEA
Genome Projectbasolateral plasma membrane
GO:0043235
ISO
IEA
Genome Projectreceptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000494Receptor L-domain
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR006211Furin-like cysteine-rich domain
IPR006212Furin-like repeat
IPR008266Tyrosine-protein kinase, active site
IPR009030Growth factor receptor cysteine-rich domain
IPR011009Protein kinase-like domain
IPR016245Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR017441Protein kinase, ATP binding site
IPR020635Tyrosine-protein kinase, catalytic domain

No MapMan annotations defined for this gene.