Gene: ENSMUSG00000059146 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000059146
Transcript Identifier
ENSMUST00000195262
Gene Type
Coding gene
Location
7 : 78192559-78577783 : negative

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P019110
(5 genes in 2 species)
specific family
Duplication type
Tandem duplicate   and   Block duplicate

Descriptions

gene_descr
neurotrophic tyrosine kinase, receptor, type 3

Identifiers

Type Value
UniprotA0A0A6YWL7
MGI97385

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000187
ISO
Genome Projectactivation of MAPK activity
GO:0001933
ISO
Genome Projectnegative regulation of protein phosphorylation
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007169
ISO
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284
ISO
Genome Projectpositive regulation of cell proliferation
GO:0010628
ISO
Genome Projectpositive regulation of gene expression
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0030335
ISO
Genome Projectpositive regulation of cell migration
GO:0032148
ISO
Genome Projectactivation of protein kinase B activity
GO:0033138
ISO
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0038179
ISO
Genome Projectneurotrophin signaling pathway
GO:0042490
IMP
Genome Projectmechanoreceptor differentiation
GO:0043065
IDA
Genome Projectpositive regulation of apoptotic process
GO:0048691
IGI
Genome Projectpositive regulation of axon extension involved in regeneration
GO:0050927
ISO
Genome Projectpositive regulation of positive chemotaxis
GO:0051965
IDA
Genome Projectpositive regulation of synapse assembly
GO:0070306
IGI
Genome Projectlens fiber cell differentiation
GO:0090630
ISO
Genome Projectactivation of GTPase activity
GO:2000251
ISO
Genome Projectpositive regulation of actin cytoskeleton reorganization

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0002039
ISO
Genome Projectp53 binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0005030
ISO
IEA
Genome Projectneurotrophin receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
Genome Projectcytoplasm
GO:0005887
IEA
Genome Projectintegral component of plasma membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0043235
ISO
Genome Projectreceptor complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000372Leucine-rich repeat N-terminal domain
IPR000483Cysteine-rich flanking region, C-terminal
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001611Leucine-rich repeat
IPR002011Tyrosine-protein kinase, receptor class II, conserved site
IPR003599Immunoglobulin subtype
IPR007110Immunoglobulin-like domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR013098Immunoglobulin I-set
IPR013151Immunoglobulin
IPR013783Immunoglobulin-like fold
IPR017441Protein kinase, ATP binding site
IPR020446Tyrosine-protein kinase, neurotrophic receptor, type 3
IPR020635Tyrosine-protein kinase, catalytic domain
IPR020777Tyrosine-protein kinase, neurotrophic receptor
IPR031635Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain

No MapMan annotations defined for this gene.