Gene: ENSMUSG00000056999 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000056999
Transcript Identifier
ENSMUST00000131070
Gene Type
Coding gene
Location
19 : 37270742-37330613 : negative

Family Information

Homologous gene family
HOM03P127429
(orphan gene)
specific family

Descriptions

gene_descr
insulin degrading enzyme

Identifiers

Type Value
UniprotF6RPJ9
MGI96412

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006508
ISO
IEA
Genome Projectproteolysis
GO:0008340
ISO
IEA
Genome Projectdetermination of adult lifespan
GO:0010815
ISO
IEA
Genome Projectbradykinin catabolic process
GO:0010992
ISO
IEA
Genome Projectubiquitin homeostasis
GO:0016485
IBA
Genome Projectprotein processing
GO:0032461
ISO
IEA
Genome Projectpositive regulation of protein oligomerization
GO:0042447
IBA
IEA
Genome Projecthormone catabolic process
GO:0043171
IBA
Genome Projectpeptide catabolic process
GO:0044257
IEA
Genome Projectcellular protein catabolic process
GO:0045861
IEA
Genome Projectnegative regulation of proteolysis
GO:0050435
ISO, IBA
IEA
Genome Projectbeta-amyloid metabolic process
GO:0051260
ISO
IEA
Genome Projectprotein homooligomerization
GO:0051289
IEA
Genome Projectprotein homotetramerization
GO:0051291
IEA
Genome Projectprotein heterooligomerization
GO:0051603
ISO, IBA
IEA
Genome Projectproteolysis involved in cellular protein catabolic process
GO:1901142
ISO
IEA
Genome Projectinsulin metabolic process
GO:1901143
ISO
IEA
Genome Projectinsulin catabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001540
IEA
Genome Projectbeta-amyloid binding
GO:0001948
ISO
IEA
Genome Projectglycoprotein binding
GO:0003824
IEA
Genome Projectcatalytic activity
GO:0004222
ISO, IBA
IEA
Genome Projectmetalloendopeptidase activity
GO:0005102
ISO
IEA
Genome Projectreceptor binding
GO:0005524
ISO
IEA
Genome ProjectATP binding
GO:0008270
ISO, IBA
IEA
Genome Projectzinc ion binding
GO:0016887
IEA
Genome ProjectATPase activity
GO:0017046
IEA
Genome Projectpeptide hormone binding
GO:0031626
IEA
Genome Projectbeta-endorphin binding
GO:0042277
ISO
IEA
Genome Projectpeptide binding
GO:0042803
ISO
IEA
Genome Projectprotein homodimerization activity
GO:0043130
ISO
IEA
Genome Projectubiquitin binding
GO:0043559
ISO
IEA
Genome Projectinsulin binding
GO:0046872
IEA
Genome Projectmetal ion binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005615
ISO
IEA
Genome Projectextracellular space
GO:0005634
IEA
Genome Projectnucleus
GO:0005654
ISO
IEA
Genome Projectnucleoplasm
GO:0005737
ISO
IEA
Genome Projectcytoplasm
GO:0005739
IDA
ISO
IEA
Genome Projectmitochondrion
GO:0005777
ISO
IEA
Genome Projectperoxisome
GO:0005782
IBA
IEA
Genome Projectperoxisomal matrix
GO:0005829
ISO, IBA
IEA
Genome Projectcytosol
GO:0009986
ISO
IEA
Genome Projectcell surface
GO:0031597
IEA
Genome Projectcytosolic proteasome complex

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR001431Peptidase M16, zinc-binding site
IPR007863Peptidase M16, C-terminal
IPR011237Peptidase M16 domain
IPR011249Metalloenzyme, LuxS/M16 peptidase-like
IPR011765Peptidase M16, N-terminal
IPR032632Peptidase M16, middle/third domain

No MapMan annotations defined for this gene.