Gene: ENSMUSG00000055254 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000055254
Transcript Identifier
ENSMUST00000079828
Gene Type
Coding gene
Location
13 : 58808729-59128353 : positive

Family Information

Homologous gene family
HOM03P000004
(1817 genes in 37 species)
specific family
Orthologous gene family
ORTHO03P019110
(5 genes in 2 species)
specific family

Descriptions

gene_descr
neurotrophic tyrosine kinase, receptor, type 2

Identifiers

Type Value
UniprotP15209
MGI97384

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001570
IMP
Genome Projectvasculogenesis
GO:0001764
IMP
Genome Projectneuron migration
GO:0006468
IEA
Genome Projectprotein phosphorylation
GO:0007169
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275
IEA
Genome Projectmulticellular organismal development
GO:0007399
IEA
Genome Projectnervous system development
GO:0007528
IMP
Genome Projectneuromuscular junction development
GO:0007612
IMP
Genome Projectlearning
GO:0007623
IEP
Genome Projectcircadian rhythm
GO:0007631
IMP
Genome Projectfeeding behavior
GO:0008284
ISS
Genome Projectpositive regulation of cell proliferation
GO:0010628
IMP
Genome Projectpositive regulation of gene expression
GO:0010976
IDA
Genome Projectpositive regulation of neuron projection development
GO:0014047
IPI
Genome Projectglutamate secretion
GO:0014068
ISS
Genome Projectpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0016310
IEA
Genome Projectphosphorylation
GO:0018108
IEA
Genome Projectpeptidyl-tyrosine phosphorylation
GO:0019222
IMP
Genome Projectregulation of metabolic process
GO:0021954
IMP
Genome Projectcentral nervous system neuron development
GO:0021987
IMP
Genome Projectcerebral cortex development
GO:0030154
IEA
Genome Projectcell differentiation
GO:0030182
IMP
Genome Projectneuron differentiation
GO:0031547
IDA
ISO
IEA
Genome Projectbrain-derived neurotrophic factor receptor signaling pathway
GO:0033138
IMP
Genome Projectpositive regulation of peptidyl-serine phosphorylation
GO:0035584
IMP
Genome Projectcalcium-mediated signaling using intracellular calcium source
GO:0038179
IEA
Genome Projectneurotrophin signaling pathway
GO:0042490
IMP
Genome Projectmechanoreceptor differentiation
GO:0043087
IDA
Genome Projectregulation of GTPase activity
GO:0043410
ISS
Genome Projectpositive regulation of MAPK cascade
GO:0043524
ISS
Genome Projectnegative regulation of neuron apoptotic process
GO:0046548
IMP
Genome Projectretinal rod cell development
GO:0046777
ISS
Genome Projectprotein autophosphorylation
GO:0048709
IMP
Genome Projectoligodendrocyte differentiation
GO:0048935
IMP
Genome Projectperipheral nervous system neuron development
GO:0050772
ISS
Genome Projectpositive regulation of axonogenesis
GO:0051896
IMP
Genome Projectregulation of protein kinase B signaling
GO:0051965
IDA
Genome Projectpositive regulation of synapse assembly
GO:0060041
IMP
Genome Projectretina development in camera-type eye
GO:0060291
IMP
Genome Projectlong-term synaptic potentiation
GO:0071230
IDA
Genome Projectcellular response to amino acid stimulus
GO:2000324
ISO
Genome Projectpositive regulation of glucocorticoid receptor signaling pathway
GO:2000811
IDA
Genome Projectnegative regulation of anoikis

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000166
IEA
Genome Projectnucleotide binding
GO:0004672
IEA
Genome Projectprotein kinase activity
GO:0004713
IEA
Genome Projectprotein tyrosine kinase activity
GO:0004714
IEA
Genome Projecttransmembrane receptor protein tyrosine kinase activity
GO:0005030
IEA
Genome Projectneurotrophin receptor activity
GO:0005515
IPI
Genome Projectprotein binding
GO:0005524
IEA
Genome ProjectATP binding
GO:0016301
IEA
Genome Projectkinase activity
GO:0016740
IEA
Genome Projecttransferase activity
GO:0042803
ISS
Genome Projectprotein homodimerization activity
GO:0043121
IDA
ISS, ISO
Genome Projectneurotrophin binding
GO:0048403
IDA
Genome Projectbrain-derived neurotrophic factor binding
GO:0060175
IDA
ISO
IEA
Genome Projectbrain-derived neurotrophic factor-activated receptor activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005622
IMP
Genome Projectintracellular
GO:0005768
IDA
IEA
Genome Projectendosome
GO:0005829
IDA
Genome Projectcytosol
GO:0005886
IDA
IEA
Genome Projectplasma membrane
GO:0005887
ISS, ISO
IEA
Genome Projectintegral component of plasma membrane
GO:0010008
IEA
Genome Projectendosome membrane
GO:0016020
IEA
Genome Projectmembrane
GO:0016021
IEA
Genome Projectintegral component of membrane
GO:0043195
IDA
Genome Projectterminal bouton
GO:0043235
ISO
IEA
Genome Projectreceptor complex
GO:0045211
IDA
Genome Projectpostsynaptic membrane
GO:0097481
IDA
Genome Projectneuronal postsynaptic density

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
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InterPro Description
IPR000372Leucine-rich repeat N-terminal domain
IPR000483Cysteine-rich flanking region, C-terminal
IPR000719Protein kinase domain
IPR001245Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001611Leucine-rich repeat
IPR002011Tyrosine-protein kinase, receptor class II, conserved site
IPR003598Immunoglobulin subtype 2
IPR007110Immunoglobulin-like domain
IPR008266Tyrosine-protein kinase, active site
IPR011009Protein kinase-like domain
IPR013098Immunoglobulin I-set
IPR013783Immunoglobulin-like fold
IPR017441Protein kinase, ATP binding site
IPR020455Tyrosine-protein kinase, neurotrophic receptor, type 2
IPR020635Tyrosine-protein kinase, catalytic domain
IPR020777Tyrosine-protein kinase, neurotrophic receptor
IPR031635Tyrosine-protein kinase receptor NTRK, C2-Ig-like domain

No MapMan annotations defined for this gene.