Gene: ENSMUSG00000052593 (Mus musculus)

Overview top

Gene Identifier
ENSMUSG00000052593
Transcript Identifier
ENSMUST00000101551
Gene Type
Coding gene
Location
12 : 21325276-21373432 : negative

Family Information

Homologous gene family
HOM03P008887
(9 genes in 4 species)
specific family
Orthologous gene family
ORTHO03P028789
(4 genes in 4 species)
specific family

Descriptions

gene_descr
a disintegrin and metallopeptidase domain 17

Identifiers

Type Value
UniprotE9PXU2
MGI1096335

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Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0001666
ISO
IEA
Genome Projectresponse to hypoxia
GO:0001934
ISO
IEA
Genome Projectpositive regulation of protein phosphorylation
GO:0006508
ISO
IEA
Genome Projectproteolysis
GO:0006509
ISO
IEA
Genome Projectmembrane protein ectodomain proteolysis
GO:0007155
ISO
IEA
Genome Projectcell adhesion
GO:0007173
ISO
IEA
Genome Projectepidermal growth factor receptor signaling pathway
GO:0007220
ISO
IEA
Genome ProjectNotch receptor processing
GO:0008284
ISO
IEA
Genome Projectpositive regulation of cell proliferation
GO:0010820
ISO
IEA
Genome Projectpositive regulation of T cell chemotaxis
GO:0030307
ISO
IEA
Genome Projectpositive regulation of cell growth
GO:0030335
ISO
IEA
Genome Projectpositive regulation of cell migration
GO:0030512
ISO
IEA
Genome Projectnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0031659
ISO
IEA
Genome Projectpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0032496
ISO
IEA
Genome Projectresponse to lipopolysaccharide
GO:0032722
ISO
IEA
Genome Projectpositive regulation of chemokine production
GO:0033627
ISO
IEA
Genome Projectcell adhesion mediated by integrin
GO:0035313
IEA
Genome Projectwound healing, spreading of epidermal cells
GO:0035625
ISO
IEA
Genome Projectepidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0045741
ISO
IEA
Genome Projectpositive regulation of epidermal growth factor-activated receptor activity
GO:0050830
ISO
IEA
Genome Projectdefense response to Gram-positive bacterium
GO:0051088
ISO
IEA
Genome ProjectPMA-inducible membrane protein ectodomain proteolysis
GO:0055099
ISO
IEA
Genome Projectresponse to high density lipoprotein particle

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004222
ISO
IEA
Genome Projectmetalloendopeptidase activity
GO:0005112
ISO
IEA
Genome ProjectNotch binding
GO:0005138
ISO
IEA
Genome Projectinterleukin-6 receptor binding
GO:0005178
ISO
IEA
Genome Projectintegrin binding
GO:0005515
IPI
Genome Projectprotein binding
GO:0008237
ISO
IEA
Genome Projectmetallopeptidase activity
GO:0008270
IEA
Genome Projectzinc ion binding
GO:0030165
ISO
IEA
Genome ProjectPDZ domain binding

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005737
IDA
ISO
IEA
Genome Projectcytoplasm
GO:0005887
ISO
IEA
Genome Projectintegral component of plasma membrane
GO:0005911
ISO
IEA
Genome Projectcell-cell junction
GO:0005925
ISO
IEA
Genome Projectfocal adhesion
GO:0009986
ISO
IEA
Genome Projectcell surface
GO:0015629
ISO
IEA
Genome Projectactin cytoskeleton
GO:0016020
ISO
IEA
Genome Projectmembrane
GO:0016324
ISO
IEA
Genome Projectapical plasma membrane
GO:0032587
ISO
IEA
Genome Projectruffle membrane
GO:0045121
ISO
IEA
Genome Projectmembrane raft

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources:   Primary     Orthology     Homology  
Show redundant parents:  
 
InterPro Description
IPR001590Peptidase M12B, ADAM/reprolysin
IPR001762Disintegrin domain
IPR002870Peptidase M12B, propeptide
IPR024079Metallopeptidase, catalytic domain
IPR032029ADAM17, membrane-proximal domain

No MapMan annotations defined for this gene.